Academic Journal
Calcium carbonate microparticles as carriers of 224Ra: Impact of specific activity in mice with intraperitoneal ovarian cancer
| العنوان: | Calcium carbonate microparticles as carriers of 224Ra: Impact of specific activity in mice with intraperitoneal ovarian cancer |
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| المؤلفون: | Li, Ruth Gong, Napoli, Elisa, Jorstad, Ida Sofie, Bønsdorff, Tina Bjørnlund, Juzeniene, Asta, Bruland, Øyvind Sverre, Larsen, Roy H., Westrøm, Sara |
| المصدر: | 1874-4710. |
| سنة النشر: | 2021 |
| المجموعة: | Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
| الوصف: | Background: Patients with advanced-stage ovarian cancer face a poor prognosis because of recurrent peritoneal cavity metastases following surgery and chemotherapy. Alpha-emitters may enable the efficient treatment of such disseminated diseases because of their short range and highly energetic radiation. Radium-224 is a candidate α-emitter due to its convenient 3.6-day half-life, with more than 90% of the decay energy originating from α-particles. However, its inherent skeletal accumulation must be overcome to facilitate intraperitoneal delivery of the radiation dose. Therefore, 224Ra-labeled CaCO3 microparticles have been developed. Objective: The antitumor effect of CaCO3 microparticles as a carrier for 224Ra was investigated, with an emphasis on the ratio of activity to mass dose of CaCO3, that is, specific activity. Methods: Nude athymic mice were inoculated intraperitoneally with human ovarian cancer cells (ES-2) and treated with a single intraperitoneal injection of 224Ra-labeled CaCO3 microparticles with varying combinations of mass and activity dose, or cationic 224Ra in solution. Survival and ascites volume at sacrifice were evaluated. Results: Significant therapeutic effect was achieved for all tested specific activities ranging from 0.4 to 4.6 kBq/mg. Although treatment with a mean activity dose of 1305 kBq/kg of cationic 224Ra prolonged the survival compared with the control, equivalent median survival could be achieved with 224Ra-labeled microparticles with a mean dose of only 420 kBq/kg. The best outcome was achieved with the highest specific activities (2.6 and 4.6 kBq/mg). Conclusion: Radium-224-labeled CaCO3 microparticles present a promising therapy against cancer dissemination in body cavities. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | http://urn.nb.no/URN:NBN:no-93703; Li, Ruth Gong Napoli, Elisa Jorstad, Ida Sofie Bønsdorff, Tina Bjørnlund Juzeniene, Asta Bruland, Øyvind Sverre Larsen, Roy H. Westrøm, Sara . Calcium carbonate microparticles as carriers of 224Ra: Impact of specific activity in mice with intraperitoneal ovarian cancer. Current Radiopharmaceuticals. 2021, 14(2), 145-153; http://hdl.handle.net/10852/91106; 1922360; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Current Radiopharmaceuticals&rft.volume=14&rft.spage=145&rft.date=2021; Current Radiopharmaceuticals; 14; 145; 153; https://doi.org/10.2174/1874471013666201201102056; URN:NBN:no-93703; Fulltext https://www.duo.uio.no/bitstream/handle/10852/91106/4/0009CRP.pdf |
| DOI: | 10.2174/1874471013666201201102056 |
| الاتاحة: | http://hdl.handle.net/10852/91106 http://urn.nb.no/URN:NBN:no-93703 https://doi.org/10.2174/1874471013666201201102056 |
| Rights: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.80B91830 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/1874471013666201201102056 |
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