Academic Journal
Cytokines in Spondyloarthritis and Inflammatory Bowel Diseases: From Pathogenesis to Therapeutic Implications
| العنوان: | Cytokines in Spondyloarthritis and Inflammatory Bowel Diseases: From Pathogenesis to Therapeutic Implications |
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| المؤلفون: | Felice C., Dal Buono A., Gabbiadini R., Rattazzi M., Armuzzi A. |
| المساهمون: | Felice, C., Dal Buono, A., Gabbiadini, R., Rattazzi, M., Armuzzi, A. |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | cytokine, gut–joint axi, inflammatory bowel disease, psoriatic arthriti, rheumatoid arthriti, spondyloarthritis |
| الوصف: | Spondyloarthritis and inflammatory bowel diseases are chronic immune disorders of the joints and the gut that often coexist in the same patient, increasing the burden of each disorder, worsening patients’ quality of life, and influencing therapeutic strategies. Genetic predisposition, environmental triggers, microbiome features, immune cell trafficking, and soluble factors such as cytokines contribute to the pathogenesis of both articular and intestinal inflammation. Most of the molecular targeted biological therapies developed over the last two decades were based on evidence that specific cytokines may be involved in these immune diseases. Despite pro-inflammatory cytokine pathways sharing the pathogenesis of both articular and gut diseases (i.e., tumor necrosis factor and interleukin-23), several other cytokines (i.e., interleukin-17) may be differently involved in the tissue damage process, depending on the specific disease and the organ involved in inflammation, making difficult the identification of a therapeutic plan that is efficacious for both inflammatory manifestations. In this narrative review, we comprehensively summarize the current knowledge on cytokine involvement in spondyloarthritis and inflammatory bowel diseases, underlining similarities and differences among their pathogenetic pathways; finally, we provide an overview of current and potential future treatment strategies to simultaneously target both articular and gut immune disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36835369; info:eu-repo/semantics/altIdentifier/wos/WOS:000938700700001; volume:24; issue:4; firstpage:3957; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/11577/3474282; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85149023926 |
| DOI: | 10.3390/ijms24043957 |
| الاتاحة: | https://hdl.handle.net/11577/3474282 https://doi.org/10.3390/ijms24043957 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.80938FA4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms24043957 |
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