Academic Journal
Development of simplified heterocyclic acetogenin analogues as potent and selective Trypanosoma brucei inhibitors
| العنوان: | Development of simplified heterocyclic acetogenin analogues as potent and selective Trypanosoma brucei inhibitors |
|---|---|
| المؤلفون: | Florence, Gordon J., Fraser, Andrew L., Gould, Eoin R., King, Elizabeth F., Menzies, Stefanie K., Morris, Joanne C., Thomson, Marie I., Tulloch, Lindsay B., Zacharova, Marija K., Smith, Terry K. |
| المصدر: | Florence , G J , Fraser , A L , Gould , E R , King , E F , Menzies , S K , Morris , J C , Thomson , M I , Tulloch , L B , Zacharova , M K & Smith , T K 2016 , ' Development of simplified heterocyclic acetogenin analogues as potent and selective Trypanosoma brucei inhibitors ' , ChemMedChem , vol. 11 , no. 14 , pp. 1503-1506 . https://doi.org/10.1002/cmdc.201600210 |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | [3+2] cycloaddition, Drug discovery, Natural product analogues, Trypanosomatids |
| الوصف: | Neglected tropical diseases caused by parasitic infections are an on-going and increasing concern and burden to human and animal health, having the most devastating effect on the world’s poorest countries. Building upon our previously reported triazole analogues, in this study we describe the synthesis and biological testing of other novel heterocyclic acetogenin-inspired derivatives, namely 3,5 isoxazoles, furoxans and furazans. Several of these compounds maintain low micromolar levels of inhibition against Trypanosoma brucei , whilst having no observable inhibitory effect on mammalian cells, leading to the possibility of novel lead compounds for selective treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1002/cmdc.201600210 |
| الاتاحة: | https://risweb.st-andrews.ac.uk/portal/en/researchoutput/development-of-simplified-heterocyclic-acetogenin-analogues-as-potent-and-selective-trypanosoma-brucei-inhibitors(6a1ae42a-9a93-4f5e-bdd5-9144a9a82588).html https://doi.org/10.1002/cmdc.201600210 https://research-repository.st-andrews.ac.uk/bitstream/10023/10977/1/cmdc201600210_revised_PURE.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8092729C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/cmdc.201600210 |
|---|