Academic Journal
A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide‐induced anemic rats
| العنوان: | A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide‐induced anemic rats |
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| المؤلفون: | Zhang, Li, Gong, Amy G. W., Riaz, Kashif, Deng, Jun Y., Ho, Chih M., Lin, Huang Q., Dong, Tina T. X., Lee, Yi‐Kuen, Tsim, Karl W. K. |
| المساهمون: | Glaucoma Research Foundation |
| المصدر: | FEBS Open Bio ; volume 7, issue 3, page 318-323 ; ISSN 2211-5463 2211-5463 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2017 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | By using a feedback system control scheme, the best combination of formononetin, ononin, calycosin, and calycosin‐7‐ O ‐β‐ d ‐glucoside derived from Astragali Radix was shown to activate a hypoxia response element, a regulator for erythropoietin (EPO) transcription, in kidney fibroblast. In cyclophosphamide‐induced anemic rats, the treatment of combined flavonoids, or EPO, improved the levels of red blood cells, white blood cells, hemoglobin, and hematocrit. In addition, the altered levels of antioxidant capacity, super oxidase dismutase, and malondialdehyde, triggered in anemic rats, were restored to control levels by the treatment of flavonoids. Here, we proposed a possible therapy by using the common flavonoids in treating anemia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/2211-5463.12146 |
| الاتاحة: | http://dx.doi.org/10.1002/2211-5463.12146 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F2211-5463.12146 https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/2211-5463.12146 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.807A675E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/2211-5463.12146 |
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