Academic Journal
Is maximum tolerated dose (MTD) chemotherapy scheduling optimal for glioblastoma multiforme?
| العنوان: | Is maximum tolerated dose (MTD) chemotherapy scheduling optimal for glioblastoma multiforme? |
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| المؤلفون: | Kao, Chiu Yen, Mohammadi, Seyyed Abbas, Yousefnezhad, Mohsen |
| المصدر: | Kao , C Y , Mohammadi , S A & Yousefnezhad , M 2024 , ' Is maximum tolerated dose (MTD) chemotherapy scheduling optimal for glioblastoma multiforme? ' , Communications in Nonlinear Science and Numerical Simulation , vol. 139 , 108292 . https://doi.org/10.1016/j.cnsns.2024.108292 |
| سنة النشر: | 2024 |
| المجموعة: | Discovery - University of Dundee Online Publications |
| مصطلحات موضوعية: | Analytical solution, Bang-bang solution, Chemotherapy scheduling, Glioblastoma multiforme, Optimal control of PDEs, /dk/atira/pure/subjectarea/asjc/2600/2612, name=Numerical Analysis, /dk/atira/pure/subjectarea/asjc/2600/2611, name=Modelling and Simulation, /dk/atira/pure/subjectarea/asjc/2600/2604, name=Applied Mathematics |
| الوصف: | In this study, we investigate a control problem involving a reaction–diffusion partial differential equation (PDE). Specifically, the focus is on optimizing the chemotherapy scheduling for brain tumor treatment to minimize the remaining tumor cells post-chemotherapy. Our findings establish that a bang-bang increasing function is the unique solution, affirming the MTD scheduling as the optimal chemotherapy profile. Several numerical experiments on a real brain image with parameters from clinics are conducted for tumors located in the frontal lobe, temporal lobe, or occipital lobe. They confirm our theoretical results and suggest a correlation between the proliferation rate of the tumor and the effectiveness of the optimal treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1016/j.cnsns.2024.108292 |
| الاتاحة: | https://discovery.dundee.ac.uk/en/publications/2314b751-acdf-409c-b44a-ee829bdaba4c https://doi.org/10.1016/j.cnsns.2024.108292 https://discovery.dundee.ac.uk/ws/files/140092527/1-s2.0-S1007570424004775-main.pdf http://www.scopus.com/inward/record.url?scp=85202699779&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8062A398 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cnsns.2024.108292 |
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