Academic Journal
Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer
| العنوان: | Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer |
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| المؤلفون: | Jia, Qingzhu, Wu, Wei, Wang, Yuqi, Alexander, Peter B., Sun, Chengdu, Gong, Zhihua, Cheng, Jia-Nan, Sun, Huaibo, Guan, Yanfang, Xia, Xuefeng, Yang, Ling, Yi, Xin, Wan, Yisong Y., Wang, Haidong, He, Ji, Futreal, P. Andrew, Li, Qi-Jing, Zhu, Bo |
| المصدر: | Nature Communications ; volume 9, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2018 |
| الوصف: | Combining whole exome sequencing, transcriptome profiling, and T cell repertoire analysis, we investigate the spatial features of surgically-removed biopsies from multiple loci in tumor masses of 15 patients with non-small cell lung cancer (NSCLC). This revealed that the immune microenvironment has high spatial heterogeneity such that intratumoral regional variation is as large as inter-personal variation. While the local total mutational burden (TMB) is associated with local T-cell clonal expansion, local anti-tumor cytotoxicity does not directly correlate with neoantigen abundance. Together, these findings caution against that immunological signatures can be predicted solely from TMB or microenvironmental analysis from a single locus biopsy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-018-07767-w |
| الاتاحة: | http://dx.doi.org/10.1038/s41467-018-07767-w https://www.nature.com/articles/s41467-018-07767-w.pdf https://www.nature.com/articles/s41467-018-07767-w |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.805736CD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-018-07767-w |
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