التفاصيل البيبلوغرافية
| العنوان: |
Utilizing Allenic Acids and Heterocyclic Diazo Compounds in the Synthesis of Polysubstituted Spirocyclic Butenolides and β‑Methylidene 2‑Furanones |
| المؤلفون: |
Ksenia Malkova, Ilya Tatarinov, Grigory Kantin, Dmitry Dar’in |
| سنة النشر: |
2024 |
| المجموعة: |
Smithsonian Institution: Figshare |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Microbiology, Genetics, Pharmacology, Biotechnology, Ecology, Inorganic Chemistry, Infectious Diseases, Virology, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, – h insertion, utilizing allenic acids, ii )- catalyzed, allenic acids followed, polysubstituted spirocyclic butenolides, heterocyclic diazo compounds, diverse spirocyclic scaffolds, diazo tetramic acids, furanones via rh, spirocyclic δ, spirocyclic 2, diazo oxindoles, diazo homophthalimides, two types, research revealed, promoted cyclization |
| الوصف: |
Herein, we report a novel approach for the assembly of spirocyclic Δ α,β -butenolides and β-methylidene 2-furanones via Rh(II)-catalyzed O–H insertion of heterocyclic diazo compounds into allenic acids followed by base-promoted cyclization. Utilizing various diazo heterocycles, including α-diazo homophthalimides, 3-diazo tetramic acids, and diazo oxindoles, diverse spirocyclic scaffolds were produced. The research revealed that the allenic acid substitution pattern is decisive for the product type, enabling extraordinary target compound switching between two types of spirocyclic 2-furanones with exo- and endocyclic CC bonds. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Utilizing_Allenic_Acids_and_Heterocyclic_Diazo_Compounds_in_the_Synthesis_of_Polysubstituted_Spirocyclic_Butenolides_and_Methylidene_2_Furanones/25125435 |
| DOI: |
10.1021/acs.joc.3c02474.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.joc.3c02474.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.8041C118 |
| قاعدة البيانات: |
BASE |