Academic Journal
Small animal PET with spontaneous inhalation of 15 O-labelled oxygen gases: Longitudinal assessment of cerebral oxygen metabolism in a rat model of neonatal hypoxic-ischaemic encephalopathy
| العنوان: | Small animal PET with spontaneous inhalation of 15 O-labelled oxygen gases: Longitudinal assessment of cerebral oxygen metabolism in a rat model of neonatal hypoxic-ischaemic encephalopathy |
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| المؤلفون: | Shimochi, Saeka, Ihalainen, Jukka, Parikka, Vilhelmiina, Kudomi, Nobuyuki, Tolvanen, Tuula, Hietanen, Ari, Kokkomäki, Esa, Johansson, Stefan, Tsuji, Masahiro, Kanaya, Shigehiko, Yatkin, Emrah, Grönroos, Tove J, Iida, Hidehiro |
| المصدر: | Journal of Cerebral Blood Flow & Metabolism ; volume 44, issue 6, page 1024-1038 ; ISSN 0271-678X 1559-7016 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2023 |
| الوصف: | Perinatal hypoxic-ischaemic encephalopathy (HIE) is the leading cause of irreversible brain damage resulting in serious neurological dysfunction among neonates. We evaluated the feasibility of positron emission tomography (PET) methodology with 15 O-labelled gases without intravenous or tracheal cannulation for assessing temporal changes in cerebral blood flow ( CBF) and cerebral metabolic rate for oxygen ( CMRO 2 ) in a neonatal HIE rat model. Sequential PET scans with spontaneous inhalation of 15 O-gases mixed with isoflurane were performed over 14 days after the hypoxic-ischaemic insult in HIE pups and age-matched controls. CBF and CMRO 2 in the injured hemispheres of HIE pups remarkably decreased 2 days after the insult, gradually recovering over 14 days in line with their increase found in healthy controls according to their natural maturation process. The magnitude of hemispheric tissue loss histologically measured after the last PET scan was significantly correlated with the decreases in CBF and CMRO 2. This fully non-invasive imaging strategy may be useful for monitoring damage progression in neonatal HIE and for evaluating potential therapeutic outcomes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/0271678x231220691 |
| DOI: | 10.1177/0271678X231220691 |
| الاتاحة: | https://doi.org/10.1177/0271678x231220691 https://journals.sagepub.com/doi/pdf/10.1177/0271678X231220691 https://journals.sagepub.com/doi/full-xml/10.1177/0271678X231220691 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.804105E2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/0271678x231220691 |
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