Academic Journal
أعرض في EDS

A Novel Combination of Four Flavonoids Derived from Astragali Radix Relieves the Symptoms of Cyclophosphamide-Induced Anemic Rats

التفاصيل البيبلوغرافية
العنوان: A Novel Combination of Four Flavonoids Derived from Astragali Radix Relieves the Symptoms of Cyclophosphamide-Induced Anemic Rats
المؤلفون: Zhang, Li Wendy, Gong, Guo-wei, Riaz, Kashif, Deng, Jun Y., Ho, Chih M., Lin, Huangquan, Dong, Ting Xia, Lee, Yi-Kuen, Tsim, Karl Wah Keung
سنة النشر: 2017
المجموعة: The Hong Kong University of Science and Technology: HKUST Institutional Repository
مصطلحات موضوعية: Feedback system control, Flavonoids combination, Hematological parameters
الوصف: By using a feedback system control scheme, the best combination of formononetin, ononin, calycosin, and calycosin-7-O-β-d-glucoside derived from Astragali Radix was shown to activate a hypoxia response element, a regulator for erythropoietin (EPO) transcription, in kidney fibroblast. In cyclophosphamide-induced anemic rats, the treatment of combined flavonoids, or EPO, improved the levels of red blood cells, white blood cells, hemoglobin, and hematocrit. In addition, the altered levels of antioxidant capacity, super oxidase dismutase, and malondialdehyde, triggered in anemic rats, were restored to control levels by the treatment of flavonoids. Here, we proposed a possible therapy by using the common flavonoids in treating anemia. © 2016 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 2211-5463
Relation: http://repository.ust.hk/ir/Record/1783.1-81807; FEBS Open Bio, v. 7, (3), 1 March 2017, p. 318-323; https://doi.org/10.1002/2211-5463.12146; http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=2211-5463&rft.volume=&rft.issue=&rft.date=2016&rft.spage=1&rft.aulast=Zhang&rft.aufirst=Li&rft.atitle=A+novel+combination+of+four+flavonoids+deriving+from+Astragali+Radix+relieves+the+symptoms+of+cyclophosphamide-induced+anemic+rats&rft.title=FEBS+Open+Bio; http://www.scopus.com/record/display.url?eid=2-s2.0-85028022177&origin=inward; http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000400298500002
DOI: 10.1002/2211-5463.12146
الاتاحة: http://repository.ust.hk/ir/Record/1783.1-81807
https://doi.org/10.1002/2211-5463.12146
http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=2211-5463&rft.volume=&rft.issue=&rft.date=2016&rft.spage=1&rft.aulast=Zhang&rft.aufirst=Li&rft.atitle=A+novel+combination+of+four+flavonoids+deriving+from+Astragali+Radix+relieves+the+symptoms+of+cyclophosphamide-induced+anemic+rats&rft.title=FEBS+Open+Bio
http://www.scopus.com/record/display.url?eid=2-s2.0-85028022177&origin=inward
http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000400298500002
رقم الانضمام: edsbas.803DE1F0
قاعدة البيانات: BASE
الوصف
تدمد:22115463
DOI:10.1002/2211-5463.12146