التفاصيل البيبلوغرافية
| العنوان: |
The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study |
| المؤلفون: |
Flaatten, Hans, Wernly, Bernhard, Artigas, Antonio, Beil, Michael, van Heerden, Peter Vernon, Szczeklik, Wojciech, Elhadi, Muhammed, Zafeiridis, Tilemachos, Moreno, Rui, Cecconi, Maurizio, Boumendil, Ariane, Abosheaishaa, Hazem Maarouf, Abualqumboz, Enas M. Y., Ahmed, Abdullah Khudhur, Ahmed, Hazem, Aidoni, Zoi, Aldecoa, Cesar, Alexandru, Nica, Ali, Yasmin Khairy NasrEldin Mohamed, Al-Sadawi, Mohammed, Andersen, Kasper, Andersen, Finn H., Assis, Rui, Azab, Mohammed A., Azzam, Ahmed Y., Badawy, Mohamed Raafat, Balleby, Ida Riise, Barth, Eberhard, Ben-HAmouda, Nawfel, Besch, Guillaume, Besset, Sebastien, Bjerregaard, Anders Thais, Brix, Helene, Bruno, Raphael Romano, Brushoej, Jens, Bundgaard, Helle, Burtin, Philippe, Caillard, Anais, Canas-Perez, Isabel, Charron, Cyril, Chrisanthopoulou, Evangelia, Comellini, Vittoria, Cornet, Alex, Cubero, Patricia Jimeno, Czuczwar, Miroslaw, Dauger, Stéphane, Diaz-Rodriguez, Cristina, Dieperink, Willem, Dindane, Zouhir, Djibré, Michel, Dormans, Tom, Dullenkopf, Alexander, Dumas, Guillaume, Elgazzar, Yumna A., Eller, Philipp, Elsaka, Ahmed, Evers, Mirjam, Faltlhauser, Andreas, Ferreira, Aida Fernández, Fjølner, Jesper, Fleury, Yvan, Galbois, Arnaud, Garcon, Pierre, Garnier, Marc, Gawda, Ryszard, Ghannam, Abdelilah, Goebel, Ulrich, Gomà, Gemma, Goncalves, Bruno, Gordinho, André, Groenendijk, Martijn, Guerot, Emmanuel, Guidet, Bertrand, Gurjar, Mohan, Haake, Hendrik, Haas, Lenneke, Habib, Ayman Abdelmawgoad, Hahn, Michael, Hansen, Maria Aagaard, Hilles, Momin Majed Yousuf, Hussein, Aliae A. R. Mohamed, Iglesias, David, Joannidis, Michael, Jung, Christian, Jurcisin, Igor, Kabitz, Hans-Joachim, Kelm, Malte, Kindgen-Milles, Detlef, Klimkiewicz, Jakub, Kuhn, Karl Friedrich, Kunstein, Anselm, Kurt, Muhammed, De Lange, Dylan W., Leaver, Susannah, Lutz, Matthias, Mahmoodpoor, Ata, Maizel, Julien, Marin, Nathalie, Marsh, Brian, Megarbane, Buno, Mesotten, Dieter, Meybohm, Patrick, Meyer, Christian, Mira, Angela Prado, Namendys-Silva, Silvio a, Nedergaard, Helene Korvenius, Nseir, Saad, Oeyen, Sandra, Olasveengen, Theresa, Oliveira, Ana Isabel Pinho, Oziel, Johanna, Papadogoulas, Antonios, Perez-Torres, David, Bollen Pinto, Bernardo, Piton, Gaël, Plantefeve, Gaëtan, Poerner, Tudor, Priego, Jesús, Rabha, Ahmed, Randerath, Winfried, Raphaelen, Jean-herlé, Reper, Pascal, Rigaud, Jean-Philippe, Rivera, Susana Arias, Roberti, Andrea, Romundstad, Luis, Rovina, Nikoletta, Salah, Rehab, Saleh, Mahmoud, Sancho, Susana, de Lurdes Campos Santos, Maria, Santos, Henrique, Schaller, Stefan, Schefold, Joerg C., Schuster, Michael, Shala, Gonxhe, Sjøbø, Britt, Steiner, Stephan, Strietzel, Hans Frank, Sviri, Sigal, Swinnen, Walter, Tamayo-Lomas, Luis, Tharwat, Samar, Tomasa, Teresa, Uhrenholt, Stine, Vaissiere, Marie, Valent, Arnaud, Valette, Xavier, Vanderlinden, Thierry, Vázquez, Eric Mayor, Villamayor, Mercedes Ibarz, Villefrance, Maja, Voigt, Ingo, Wassim, Kyrillos, Welte, Martin, Wolff, Georg, Wollborn, Jakob, Zalba-Etayo, Begoña, Zegers, Marieke |
| المصدر: |
http://lobid.org/resources/99370670818906441#!, 25(1):149. |
| سنة النشر: |
2021 |
| المجموعة: |
Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: |
COVID-19, Female [MeSH], Outcome, Aged, 80 and over [MeSH], Aged [MeSH], Elderly, Humans [MeSH], Prospective Studies [MeSH], Survival Analysis [MeSH], Frail Elderly/statistics, COVID-19/therapy [MeSH], Critical Care [MeSH], COVID-19/mortality [MeSH], Frailty/mortality [MeSH], Male [MeSH], Research, Prognosis [MeSH], Frailty, Pandemia |
| الوصف: |
Background!#!The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both the triage into intensive care, and decisions regarding treatment limitations. Our study sought to determine the interaction of frailty and age in elderly COVID-19 ICU patients.!##!Methods!#!A prospective multicentre study of COVID-19 patients ≥ 70 years admitted to intensive care in 138 ICUs from 28 countries was conducted. The primary endpoint was 30-day mortality. Frailty was assessed using the clinical frailty scale. Additionally, comorbidities, management strategies and treatment limitations were recorded.!##!Results!#!The study included 1346 patients (28% female) with a median age of 75 years (IQR 72-78, range 70-96), 16.3% were older than 80 years, and 21% of the patients were frail. The overall survival at 30 days was 59% (95% CI 56-62), with 66% (63-69) in fit, 53% (47-61) in vulnerable and 41% (35-47) in frail patients (p < 0.001). In frail patients, there was no difference in 30-day survival between different age categories. Frailty was linked to an increased use of treatment limitations and less use of mechanical ventilation. In a model controlling for age, disease severity, sex, treatment limitations and comorbidities, frailty was independently associated with lower survival.!##!Conclusion!#!Frailty provides relevant prognostic information in elderly COVID-19 patients in addition to age and comorbidities. Trial registration Clinicaltrials.gov: NCT04321265 , registered 19 March 2020. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| ردمك: |
978-9937-0-6708-9
9937-0-6708-1 |
| Relation: |
https://repository.publisso.de/resource/frl:6463899; https://doi.org/10.1186/s13054-021-03551-3; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054503/ |
| DOI: |
10.1186/s13054-021-03551-3 |
| الاتاحة: |
https://repository.publisso.de/resource/frl:6463899
https://doi.org/10.1186/s13054-021-03551-3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054503/ |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.8039EDFA |
| قاعدة البيانات: |
BASE |