Academic Journal
Comparison of initial and sequential salvage brain-directed treatment in patients with 1-4 vs. 5-10 brain metastases from breast cancer (KROG 16-12)
| العنوان: | Comparison of initial and sequential salvage brain-directed treatment in patients with 1-4 vs. 5-10 brain metastases from breast cancer (KROG 16-12) |
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| المؤلفون: | Kim, Jae Sik, Kim, Kyubo, Jung, Wonguen, Shin, Kyung Hwan, Im, Seock-Ah, Kim, Hee-Jun, Kim, Yong Bae, Chang, Jee Suk, Kim, Jee Hyun, Choi, Doo Ho, Park, Yeon Hee, Kim, Dae Yong, Kim, Tae Hyun, Choi, Byung Ock, Lee, Sea-Won, Kim, Suzy, Kwon, Jeanny, Kang, Ki Mun, Chung, Woong-Ki, Kim, Kyung Su, Yoon, Won Sup, Kim, Jin Hee, Cha, Jihye, Oh, Yoon Kyeong, Kim, In Ah |
| المساهمون: | Im, Seock-Ah, Kim, In Ah |
| بيانات النشر: | Kluwer Academic Publishers |
| سنة النشر: | 2023 |
| المجموعة: | Seoul National University: S-Space |
| مصطلحات موضوعية: | Breast cancer, Brain metastasis, Overall survival, Salvage treatment, Whole-brain radiotherapy |
| الوصف: | PurposeWe aimed to compare the initial and salvage brain-directed treatment and overall survival (OS) between patients with 1-4 brain metastases (BMs) and those with 5-10 from breast cancer (BC). We also organized a decision tree to select the initial whole-brain radiotherapy (WBRT) for these patients.MethodsBetween 2008 and 2014, 471 patients were diagnosed with 1-10 BMs. They were divided into two groups based on the number of BM: 1-4 BMs (n = 337) and 5-10 BMs (n = 134). Median follow-up duration was 14.0 months.ResultsStereotactic radiosurgery (SRS)/fractionated stereotactic radiotherapy (FSRT) was the most common treatment modality (n = 120, 36%) in the 1-4 BMs group. In contrast, 80% (n = 107) of patients with 5-10 BMs were treated with WBRT. The median OS of the entire cohort, 1-4 BMs, and 5-10 BMs was 18.0, 20.9, and 13.9 months, respectively. In the multivariate analysis, the number of BM and WBRT were not associated with OS, whereas triple-negative BC and extracranial metastasis decreased OS. Physicians determined the initial WBRT based on four variables in the following order: number and location of BM, primary tumor control, and performance status. Salvage brain-directed treatment (n = 184), mainly SRS/FSRT (n = 109, 59%), prolonged OS by a median of 14.3 months.ConclusionThe initial brain-directed treatment differed notably according to the number of BM, which was chosen based on four clinical factors. In patients with <= 10 BMs, the number of BM and WBRT did not affect OS. The major salvage brain-directed treatment modality was SRS/FSRT and increased OS. ; N ; 1 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0167-6806 |
| Relation: | Breast Cancer Research and Treatment, Vol.200 No.1, pp.37-45; https://hdl.handle.net/10371/194670; 000980807400001; 2-s2.0-85158133774; 185700 |
| DOI: | 10.1007/s10549-023-06936-w |
| الاتاحة: | https://hdl.handle.net/10371/194670 https://doi.org/10.1007/s10549-023-06936-w |
| رقم الانضمام: | edsbas.803797A6 |
| قاعدة البيانات: | BASE |
| تدمد: | 01676806 |
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| DOI: | 10.1007/s10549-023-06936-w |