Academic Journal
T cell target 1 (TCT.1): A novel target molecule for human non-major histocompatibility complex-restricted T lymphocytes
| العنوان: | T cell target 1 (TCT.1): A novel target molecule for human non-major histocompatibility complex-restricted T lymphocytes |
|---|---|
| المؤلفون: | F. Mami Chouaib, C. Miossec, C. Flament, F. Triebel, T. Hercend, DEL PORTO, Paola |
| المساهمون: | F., Mami Chouaib, C., Miossec, DEL PORTO, Paola, C., Flament, F., Triebel, T., Hercend |
| بيانات النشر: | Rockefeller University Press:1114 First Avenue, Fourth Floor:New York, NY 10021:(212)327-8572, EMAIL: rupcd@rockvax.rockefeller.edu, INTERNET: http://www.rockefeller.edu/rupress, Fax: (212)327-7944 |
| سنة النشر: | 1990 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| الوصف: | We have studied two γ/δ T cell clones, E102 and E117, generated in a mixed lymphocyte culture using an allogeneic Epstein-Barr virus-transformed B cell line, E418. These clones were both found to express a molecular form of T cell receptor (TCR) infrequent in human peripheral blood, associating a V1-J1-C δ chain and a V3-JP2-C2 γ chain. Functionally, they appeared as cytotoxic T lymphocytes (CTL) with non-major histocompatibility complex (MHC) (class I and II) requiring cytotoxicity, able to kill both the immunizing (i.e., E418) and unrelated (e.g., K562, REX, F601, and KAS) target cells. A monoclonal antibody, anti-10H3, able to selectively inhibit the cytotoxic activity of the clones has been produced. This reagant defines a 43-kD molecule, designated TCT.1, with broad distribution in the hematopoietic system, that appears to be distinct from class I MHC gene products. A series of functional experiments using various effector/target cell combinations strongly suggested that TCT.1 may represent a unique TCR ligand involved in the interaction between these particular CTL clones and certain of the target cells tested, while others were likely to be recognized and killed through a TCR-independent natural killer-like pathway. Although further experimentation will be needed to strengthen our interpretation of the present data, this study provides additional evidence that some T lymphocytes, in particular of the γ/δ type, may interact specifically with target cells in a non-MHC class I/II-requiring fashion. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/2212943; volume:172; issue:4; firstpage:1071; lastpage:1082; numberofpages:12; journal:JOURNAL OF EXPERIMENTAL MEDICINE; http://hdl.handle.net/11573/44721; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0025114812; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=A1991FN85900006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a; http://www.scopus.com/inward/record.url?eid=2-s2.0-0025114812&partnerID=65&md5=89d43cbc06c5b863337a73d869996b97 |
| الاتاحة: | http://hdl.handle.net/11573/44721 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=A1991FN85900006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a http://www.scopus.com/inward/record.url?eid=2-s2.0-0025114812&partnerID=65&md5=89d43cbc06c5b863337a73d869996b97 |
| رقم الانضمام: | edsbas.8036AF56 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |