Academic Journal
Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin
| العنوان: | Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin |
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| المؤلفون: | Heras-Molina, Ana, Yeste, Natalia, Pesantez, José Luis, Astiz, Susana, Vázquez-Gómez, Marta, Bettiga, Arianna, Trevisani, Francesco, García-Contreras, Consolación, Luis-Lima, Sergio, Bassols, Anna, Porrini, Esteban, González-Bulnes, Antonio |
| المساهمون: | Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute |
| سنة النشر: | 2022 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Animal models, Intrauterine growth restriction, Obesity, Translational medicine |
| الوصف: | Intrauterine growth restriction (IUGR) and later obesity and metabolic disorders have classically been associated with maternal malnutrition, but most cases of IUGR are related to placental insufficiency. The current study, using a swine model for IUGR and obesity, aimed to determine the interaction of birth weight (categorized as low birth weight [LBW] or normal birth-weight [NBW]) and postnatal diet (categorized as maintenance diet [MD] or fattening diet [FD]) on body weight, adiposity and metabolic traits. FD induced higher body weight and adiposity (both p < 0.0001), with higher fructosamine levels (p < 0.005) and a trend toward higher HOMA-β index (p = 0.05). NBW pigs remained heavier than LBW pigs during the early juvenile period (p < 0.005), but there were no differences at later stages. There were no differences in metabolic traits during juvenile development, but there were differences in adulthood, when LBW pigs showed higher glucose and lower insulin levels than NBW pigs (both p < 0.05). These results suggest that (a) FD allows LBW offspring to achieve similar obesity in adulthood as NBW offspring, and (b) glucose metabolism is more compromised in obese LBW than obese NBW pigs. The comparison of our data with previous studies highlights significant differences between offspring with LBW induced by maternal malnutrition or placental insufficiency, which should be considered when studying the condition. ; A.H.-M. and C.G.-C. were supported by FPI National Program Grants BES-2014-070464 and BES-2017-080541, respectively. N.Y. and M.V.-G. were recipients of graduate student fellowships FPU17/01881 and FPU14/01285, respectively, from the Spanish FPU National Program. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2079-7737 |
| Relation: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/MINECO//BES-2014-070464/ES/BES-2014-070464/; info:eu-repo/grantAgreement/AEI//BES-2017-080541/ES/BES-2017-080541/; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01881/ES/IMPACTO DE LA DETECCION Y TRATAMIENTO PRECOZ DE LAS GESTANTES PORTADORAS ASINTOMATICAS DE VAGINOSIS BACTERIANA, EN LA TASA DE PARTO PRETERMINO (VB-PREM): ENSAYO CLINICO MULTICENTRICO./; info:eu-repo/grantAgreement/MECD//FPU14%2F01285/ES/FPU14%2F01285/; Publisher's version; https://doi.org/10.3390/biology11101533; Sí; Biology 11(10): 1533 (2022); http://hdl.handle.net/10261/282217; http://dx.doi.org/10.13039/501100011033; http://dx.doi.org/10.13039/501100003329 |
| DOI: | 10.3390/biology11101533 |
| DOI: | 10.13039/501100011033 |
| DOI: | 10.13039/501100003329 |
| الاتاحة: | http://hdl.handle.net/10261/282217 https://doi.org/10.3390/biology11101533 https://doi.org/10.13039/501100011033 https://doi.org/10.13039/501100003329 |
| Rights: | open |
| رقم الانضمام: | edsbas.8032EE13 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20797737 |
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| DOI: | 10.3390/biology11101533 |