Academic Journal
Localization of radiolabeled cardiac myosin-specific antibody in myocardial infarcts. Comparison with technetium-99m stannous pyrophosphate.
| العنوان: | Localization of radiolabeled cardiac myosin-specific antibody in myocardial infarcts. Comparison with technetium-99m stannous pyrophosphate. |
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| المؤلفون: | Beller, G A, Khaw, B A, Haber, E, Smith, T W |
| المصدر: | Circulation ; volume 55, issue 1, page 74-78 ; ISSN 0009-7322 1524-4539 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 1977 |
| الوصف: | The myocardial uptake of radioiodinated (Fab')2 fragments of antimyosin antibody [125I-(Fab')2] was compared with simultaneously administered 99mTc-pyrophosphate (Tc-PYP) in dogs undergoing coronary occlusion for 24 (N=6) or 72 hours (N=5). Relative concentrations of both agents in normal and infarcted myocardium were related to regional blood flow as determined by distribution of 55Sr-labeled microspheres in the same animals. There was an inverse exponential relationship between 125I-(Fab')2 localization and regional blood flow in 24 hr (r=-0.64) and 72 hr (r=-0.80) occluded animals. The greatest uptake of 125I-(Fab')2 was observed in subendocardial layers of the center of the infarct where regional flow was most severely impaired (1-10% of normal flow). Maximal localization of Tc-PYP was observed in subepicardial layers in samples from the periphery of the infarct where flow was only moderately reduced (31-50% of normal). Differences in distribution of these two agents in ischemic myocardium are probably related to differences in kinetics of exit from the blood pool. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1161/01.cir.55.1.74 |
| DOI: | 10.1161/01.CIR.55.1.74 |
| الاتاحة: | http://dx.doi.org/10.1161/01.cir.55.1.74 https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.55.1.74 |
| رقم الانضمام: | edsbas.8024846C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1161/01.cir.55.1.74 |
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