التفاصيل البيبلوغرافية
| العنوان: |
Skin protective and regenerative effects of RM191A, a novel superoxide dismutase mimetic. |
| المؤلفون: |
Shariev, A, Menounos, S, Laos, AJ, Laxman, P, Lai, D, Hua, S, Zinger, A, McRae, CR, Casbolt, LS, Combes, V, Smith, G, Hung, T-T, Dixon, KM, Thordarson, P, Mason, RS, Das, A |
| بيانات النشر: |
Elsevier BV |
| سنة النشر: |
2022 |
| المجموعة: |
University of Technology Sydney: OPUS - Open Publications of UTS Scholars |
| مصطلحات موضوعية: |
0601 Biochemistry and Cell Biology, 1101 Medical Biochemistry and Metabolomics, 1115 Pharmacology and Pharmaceutical Sciences, Animals, Epidermis, Mice, Skin, Skin Neoplasms, Superoxide Dismutase, Tetradecanoylphorbol Acetate |
| الوصف: |
Superoxide dismutase (SOD) is known to be protective against oxidative stress-mediated skin dysfunction. Here we explore the potential therapeutic activities of RM191A, a novel SOD mimetic, on skin. RM191A is a water-soluble dimeric copper (Cu2+-Cu3+)-centred polyglycine coordination complex. It displays 10-fold higher superoxide quenching activity compared to SOD as well as significant antioxidant, anti-inflammatory and immunomodulatory activities through beneficial modulation of several significant inflammatory cytokines in vitro and in vivo. We tested the therapeutic potential of RM191A in a topical gel using a human skin explant model and observed that it significantly inhibits UV-induced DNA damage in the epidermis and dermis, including cyclobutane pyrimidine dimers (CPD), 8-oxo-guanine (8-oxoG) and 8-nitroguanine (8NGO). RM191A topical gel is found to be non-toxic, non-teratogenic and readily distributed in the body of mice. Moreover, it significantly accelerates excisional wound healing, reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation and attenuates age-associated oxidative stress in skin, demonstrating both skin regenerative and geroprotective properties of RM191A. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
Print-Electronic; application/pdf |
| اللغة: |
English |
| تدمد: |
2213-2317 |
| Relation: |
Redox Biol; Redox Biol, 2021, 38, pp. 101790; http://hdl.handle.net/10453/153126 |
| الاتاحة: |
http://hdl.handle.net/10453/153126 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.801B9EB4 |
| قاعدة البيانات: |
BASE |
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