Academic Journal

Probing diffusion of water and metabolites to assess white matter microstructure in Duchenne muscular dystrophy

التفاصيل البيبلوغرافية
العنوان: Probing diffusion of water and metabolites to assess white matter microstructure in Duchenne muscular dystrophy
المؤلفون: Govaarts R, Doorenweerd N, Najac CF, Broek EM, Tamsma ME, Hollingsworth KG, Niks EH, Ronen I, Straub V, Kan HE
المصدر: NMR in Biomedicine, 2024
بيانات النشر: John Wiley and Sons Ltd
سنة النشر: 2024
المجموعة: Newcastle University Library ePrints Service
الوصف: © 2024 The Author(s). NMR in Biomedicine published by John Wiley & Sons Ltd.Duchenne muscular dystrophy (DMD) is a progressive X-linked neuromuscular disorder caused by the absence of functional dystrophin protein. In addition to muscle, dystrophin is expressed in the brain in both neurons and glial cells. Previous studies have shown altered white matter microstructure in patients with DMD using diffusion tensor imaging (DTI). However, DTI measures the diffusion properties of water, a ubiquitous molecule, making it difficult to unravel the underlying pathology. Diffusion-weighted spectroscopy (DWS) is a complementary technique which measures diffusion properties of cell-specific intracellular metabolites. Here we performed both DWS and DTI measurements to disentangle intra- and extracellular contributions to white matter changes in patients with DMD. Scans were conducted in patients with DMD (15.5 ± 4.6 y/o) and age- and sex-matched healthy controls (16.3 ± 3.3 y/o). DWS measurements were obtained in a volume of interest (VOI) positioned in the left parietal white matter. Apparent diffusion coefficients (ADCs) were calculated for total N-acetylaspartate (tNAA), choline compounds (tCho), and total creatine (tCr). The tNAA/tCr and tCho/tCr ratios were calculated from the non-diffusion-weighted spectrum. Mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD), and fractional anisotropy of water within the VOI were extracted from DTI measurements. DWS and DTI data from patients with DMD (respectively n = 20 and n = 18) and n = 10 healthy controls were included. No differences in metabolite ADC or in concentration ratios were found between patients with DMD and controls. In contrast, water diffusion (MD, t = −2.727, p = 0.011; RD, t = −2.720, p = 0.011; AD, t = −2.715, p = 0.012) within the VOI was significantly higher in patients compared with healthy controls. Taken together, our study illustrates the potential of combining DTI and DWS to gain a better understanding of microstructural changes and ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: unknown
Relation: https://eprints.ncl.ac.uk/299868; https://eprints.ncl.ac.uk/fulltext.aspx?url=299868/B959A9E3-5FB0-4819-97CB-C8C4D579BABE.pdf&pub_id=299868
الاتاحة: https://eprints.ncl.ac.uk/299868
Rights: https://creativecommons.org/licenses/by/4.0/
رقم الانضمام: edsbas.7FF0BD92
قاعدة البيانات: BASE