Academic Journal
Characterization of atherosclerotic plaques in blood vessels with low oxygenated blood and blood pressure (Pulmonary trunk): role of growth differentiation factor-15 (GDF-15)
| العنوان: | Characterization of atherosclerotic plaques in blood vessels with low oxygenated blood and blood pressure (Pulmonary trunk): role of growth differentiation factor-15 (GDF-15) |
|---|---|
| المؤلفون: | Bonaterra, G. A., Struck, N., Zuegel, S., Schwarz, A., Mey, L., Schwarzbach, H., Strelau, J., Kinscherf, R. |
| المصدر: | http://lobid.org/resources/99370673696706441#!, 21(1):601. |
| سنة النشر: | 2021 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Mice, Inbred C57BL [MeSH], Atherosclerosis, Necrosis [MeSH], Apoptosis [MeSH], Atherosclerosis/pathology [MeSH], Pulmonary Artery/metabolism [MeSH], Hypercholesterolemic mice, Lipids/blood [MeSH], Growth Differentiation Factor 15/metabolism [MeSH], Male [MeSH], Autophagy [MeSH], Atherosclerosis/metabolism [MeSH], Pulmonary Artery/pathology [MeSH], Disease Models, Animal [MeSH], Hypercholesterolemia/complications [MeSH], Cell Proliferation [MeSH], GDF-15, Oxygen/blood [MeSH], Pulmonary trunk, Biomarkers/blood [MeSH], Humans [MeSH], Apoptosis, Macrophage, Animals [MeSH], ApoE, Atherosclerosis/physiopathology [MeSH], Knockout, ApoE [MeSH] |
| الوصف: | Background!#!Growth differentiation factor (GDF)-15 is linked to inflammation, cancer, and atherosclerosis. GDF-15 is expressed in most tissues but is extremely induced under pathological conditions. Elevated serum levels are suggested as a risk factor and a marker for cardiovascular diseases. However, the cellular sources and the effects of GDF-15 on the cardiovascular system have not been completely elucidated including progression, and morphology of atherosclerotic plaques. Thus, this work aimed to characterize the influence of GDF-15 deficiency on the morphology of atherosclerotic plaques in blood vessels with low-oxygen blood and low blood pressure as the pulmonary trunk (PT), in hypercholesterolemic ApoE!##!Methods!#!GDF-15!##!Results!#!After CED the body weight of GDF-15!##!Conclusions!#!Atherosclerotic lesions occur in both, BT and PT, however, the size is smaller in PT, possibly due to the effect of the low-oxygen blood and/or lower blood pressure. GDF-15 is involved in atherosclerotic processes in BT and PT, although different mechanisms (e.g. apoptosis) in these two vessels seem to exist. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://repository.publisso.de/resource/frl:6443538; https://doi.org/10.1186/s12872-021-02420-9; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684150/ |
| DOI: | 10.1186/s12872-021-02420-9 |
| الاتاحة: | https://repository.publisso.de/resource/frl:6443538 https://doi.org/10.1186/s12872-021-02420-9 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684150/ |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.7FC9F5D5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12872-021-02420-9 |
|---|