Academic Journal
Impact of preprocedural left ventricular systolic function on the safety and durability of percutaneous coronary intervention
| العنوان: | Impact of preprocedural left ventricular systolic function on the safety and durability of percutaneous coronary intervention |
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| المؤلفون: | Velagaleti, Raghava S., Harrell, Camden, Michalski, Justin, Lefèvre, Thierry, Windecker, Stephan, Slagboom, Ton, Saito, Shigeru, Koolen, Jacques, Waksman, Ron, Kandzari, David E. |
| المصدر: | Catheterization and Cardiovascular Interventions ; volume 103, issue 4, page 523-531 ; ISSN 1522-1946 1522-726X |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background Percutaneous coronary intervention (PCI) is considered less safe in patients with reduced ejection fraction (EF), an impression based on older data. Whether the safety and durability of contemporary PCI are different in patients with reduced EF compared with normal EF patients is unknown. Methods Patients from the BIOFLOW II, IV and V clinical trials were grouped as normal EF (≥50%) and reduced EF (30%–50%). Using multivariable logistic regression and cox proportional hazards regression, we determined relations of EF category with procedural safety (a composite of cardiac death, myocardial infarction, stroke and urgent coronary artery bypass grafting within 30 days of PCI) and target lesion failure (TLF; comprising cardiac death, target vessel myocardial infarction, target vessel revascularization within 1 year of PCI) respectively. In sensitivity analyses, we regrouped patients into EF < 45% and ≥55% and repeated the aforementioned analyses. Results In 1685 patients with normal EF (mean age 65 years; 27% women; mean EF 61%) and 259 with low EF (mean age 64 years; 17% women; mean EF 41%), 101 safety and 148 TLF events occurred. Compared with patients in the normal EF group, those with reduced EF had neither a statistically significant higher proportion of safety events, nor a higher multivariable‐adjusted risk for such events. Similarly, patients with reduced EF and normal EF did not differ in terms of TLF event proportions or multivariable‐adjusted risk for TLF. The results were similar in sensitivity analyses with EF groups redefined to create a 10% between‐group EF separation. Conclusion PCI safety and durability outcomes are similar in patients with mild‐moderately reduced EF and normal EF. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/ccd.30995 |
| الاتاحة: | http://dx.doi.org/10.1002/ccd.30995 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ccd.30995 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.7FB5167D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ccd.30995 |
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