التفاصيل البيبلوغرافية
| العنوان: |
Polyoxygenated Terpenoids and Polyketides from the Roots of Flueggea virosa and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation |
| المؤلفون: |
Ju-Chien Cheng, Yi-Ju Chen, Chi-Wen Chuang, Ya-Hsuan Chao, Hui-Chi Huang, Chia-Chi Lin, Chih-Hua Chao |
| المصدر: |
Molecules; Volume 27; Issue 23; Pages: 8548 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
SARS-CoV-2, anti-inflammatory, podovirosanes A–F, Flueggea virosa, DP4+ |
| جغرافية الموضوع: |
agris |
| الوصف: |
Six new polyoxygenated terpenoids, podovirosanes A–F (1–6), and two known polyketides (7 and 8) were isolated from the roots of F. virosa. Their structures, along with absolute configurations, were deduced using spectroscopic analysis as well as computational calculations, including TDDFT calculation of ECD spectra and GIAO NMR calculations combined with DP4+ probability analysis. Compounds 2, 3, 5, and 8 were found to reduce the phosphorylation levels of NF-κB p65 in SARS-CoV-2 pseudovirus-stimulated PMA-differentiated THP-1 cells. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Medicinal Chemistry; https://dx.doi.org/10.3390/molecules27238548 |
| DOI: |
10.3390/molecules27238548 |
| الاتاحة: |
https://doi.org/10.3390/molecules27238548 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.7F9C775C |
| قاعدة البيانات: |
BASE |