Academic Journal
Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
| العنوان: | Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe |
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| المؤلفون: | Garcia-Souto, Daniel, Bruzos, Alicia L., Diaz, Seila, Rocha, Sara, Pequeño-Valtierra, Ana, Roman-Lewis, Camila F, Alonso, Juana, Rodriguez, Rosana, Costas, Damian, Rodriguez-Castro, Jorge, Villanueva, Antonio, Valencia, José María, Annona, Giovanni, Tarallo, Andrea, Ricardo, Fernando, Bratoš Cetinić, Ana, Posada, David, Pasantes, Juan Jose, Tubio, Jose Mc, Silva, Luis |
| المساهمون: | European Commission, Ministerio de Economía y Competitividad (España), Xunta de Galicia, Centro de Estudos do Ambiente e do Mar (Portugal), Garcia-Souto, Daniel, Bruzos, Alicia L, Diaz, Seila, Rocha, Sara, Pequeño-Valtierra, Ana, Roman-Lewis, Camila F, Costas, Damian, Rodriguez-Castro, Jorge, Valencia, José María, Annona, Giovanni, Tarallo, Andrea, Bratoš Cetinić, Ana, Posada, David, Pasantes, Juan Jose, Tubio, Jose Mc |
| بيانات النشر: | eLife Sciences Publications |
| سنة النشر: | 2022 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Cancer biology, Cancer genomes, Ecology, Marine leukaemias, Transmissible cancer |
| الوصف: | 20 Pág. ; Clonally transmissible cancers are tumour lineages that are transmitted between individuals via the transfer of living cancer cells. In marine bivalves, leukaemia-like transmissible cancers, called hemic neoplasia (HN), have demonstrated the ability to infect individuals from different species. We performed whole-genome sequencing in eight warty venus clams that were diagnosed with HN, from two sampling points located more than 1000 nautical miles away in the Atlantic Ocean and the Mediterranean Sea Coasts of Spain. Mitochondrial genome sequencing analysis from neoplastic animals revealed the coexistence of haplotypes from two different clam species. Phylogenies estimated from mitochondrial and nuclear markers confirmed this leukaemia originated in striped venus clams and later transmitted to clams of the species warty venus, in which it survives as a contagious cancer. The analysis of mitochondrial and nuclear gene sequences supports all studied tumours belong to a single neoplastic lineage that spreads in the Seas of Southern Europe. ; We thank the Galicia Supercomputing Centre (CESGA) for the availability of informatic resources. JMCT, SR, SD, and JT are supported by European Research Council (ERC) Starting Grant 716,290 SCUBA CANCERS. ALB is supported by MINECO PhD fellowship BES-2016-078166. DG-S is supported by postdoctoral contract ED481B/2018/091 from Xunta de Galicia. DP is supported by ERC grant ERC-617457-PHYLOCANCER and by Spanish Ministry of Economy and Competitiveness (MINECO) grant PID2019-106247GB-I00. This research was partially funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement 730984, ASSEMBLE Plus project. CESAM got financial support from FCT/MEC (UIDP/50017/2020, UIDB/50017/2020). ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/EC/H2020/716290; info:eu-repo/grantAgreement/MINECO//BES-2016–078166; info:eu-repo/grantAgreement/EC//617457; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106247GB-I00/ES/HETEROGENEIDAD GENOMICA DE LAS CELULAS TUMORALES CIRCULANTES/; info:eu-repo/grantAgreement/EC/H2020/730984; eLife; Publisher's version; https://doi.org/10.7554/eLife.66946; Sí; eLife 10: e66946 (2022); http://hdl.handle.net/10261/272643; http://dx.doi.org/10.13039/501100000780; http://dx.doi.org/10.13039/501100003329; http://dx.doi.org/10.13039/501100010801; 2-s2.0-85123652003; https://api.elsevier.com/content/abstract/scopus_id/85123652003 |
| DOI: | 10.7554/eLife.66946 |
| DOI: | 10.13039/501100000780 |
| DOI: | 10.13039/501100003329 |
| DOI: | 10.13039/501100010801 |
| الاتاحة: | http://hdl.handle.net/10261/272643 https://doi.org/10.7554/eLife.66946 https://doi.org/10.13039/501100000780 https://doi.org/10.13039/501100003329 https://doi.org/10.13039/501100010801 https://api.elsevier.com/content/abstract/scopus_id/85123652003 |
| Rights: | open |
| رقم الانضمام: | edsbas.7F71E142 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.66946 |