Academic Journal
Clinical use of an opto-nuclear probe for hybrid sentinel node biopsy guidance: first results
| العنوان: | Clinical use of an opto-nuclear probe for hybrid sentinel node biopsy guidance: first results |
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| المؤلفون: | Vidal-Sicart, S., Seva, A., Campos, F., Sanchez, N., Alonso, I., Pahisa, J., Caparros, X., Perissinotti, A., Paredes, P., Leeuwen, F.W. van |
| المصدر: | International Journal of Computer Assisted Radiology and Surgery |
| سنة النشر: | 2019 |
| المجموعة: | Leiden Repository (Leiden University) |
| مصطلحات موضوعية: | Bi-modal, Image-guided surgery, Sentinel node, Fluorescence, SPECT, Hybrid, Dual-tracer |
| الوصف: | IntroductionGuidelines advocate the use of combined detection techniques to achieve optimal results for sentinel node (SN) biopsy. The fluorescent and radioactive (dual-) tracer ICG-Tc-99m-nanocolloid has been shown to facilitate SN biopsy in several indications. It was reported that an opto-nuclear probe permitted the detection of near-infrared fluorescence and gamma-rays. The aim of the current study was to evaluate this device in a large patient group and to test it in both open and laparoscopic surgery implications.MethodsThirty-three patients scheduled for SN biopsy with the dual-tracer were retrospectively analyzed. Pre-operative lymphoscintigraphy was performed in all patients; in 18 patients (55%), a SPECT/CT scan was also performed. Radioactive and fluorescent signatures in the SNs were assessed in vivo and ex vivo using the opto-nuclear probe.ResultsOne or more SNs were identified in all patients (identification rate 100%). Planar lymphoscintigraphic images revealed 95 hot spots that were considered as SNs. This number increased to 103 SNs when SPECT/CT was used. During surgery, 106 SNs were excised. In vivo, the fluorescence mode of the opto-nuclear probe was able to locate 79 SNs (74.5%). When the gamma-ray detection option of the same probe was used, this number increased to 99 SNs (93.3%). Ex vivo analysis revealed fluorescence in 93.3% of the excised nodes and radioactivity in 95.2%.ConclusionsThis study underlines the feasibility of using the dual-tracer/opto-nuclear probe combination for SN resections. The use of the opto-nuclear technology has been extended to laparoscopic surgery. This study also underlines the fluorescence tracing can complement traditional radio-tracing approaches. ; Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory disease |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | lumc-id: 81130479; https://hdl.handle.net/1887/121658 |
| DOI: | 10.1007/s11548-018-1816-5 |
| الاتاحة: | https://hdl.handle.net/1887/121658 https://doi.org/10.1007/s11548-018-1816-5 |
| رقم الانضمام: | edsbas.7F6688CF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s11548-018-1816-5 |
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