Academic Journal
Association between education level and access to disease-modifying treatment in patients with multiple sclerosis in France
| العنوان: | Association between education level and access to disease-modifying treatment in patients with multiple sclerosis in France |
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| المؤلفون: | Lefort, Mathilde, Dejardin, Olivier, Berger, Eric, Camdessanché, Jean-Philippe, Ciron, Jonathan, Clavelou, Pierre, de Sèze, Jerome, Debouverie, Marc, Heinzlef, Olivier, Labauge, Pierre, Laplaud, David Axel, Michel, Laure, Lebrun-Frénay, Christine, Moreau, Thibault, Pelletier, Jean, Ruet, Aurélie, Thouvenot, Eric, Vukusic, Sandra, Zephir, Hélène, Defer, Gilles, Leray, Emmanuelle |
| المساهمون: | École des Hautes Études en Santé Publique EHESP (EHESP), Département Méthodes quantitatives en santé publique (METIS), Arènes: politique, santé publique, environnement, médias (ARENES), Université de Rennes (UR)-Institut d'Études Politiques IEP - Rennes-École des Hautes Études en Santé Publique EHESP (EHESP)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS), Recherche sur les services et le management en santé (RSMS), Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), INSERM U1086, Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), CHU Clermont-Ferrand, CIC Strasbourg (Centre d’Investigation Clinique Plurithématique (CIC - P)), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nouvel Hôpital Civil de Strasbourg, Les Hôpitaux Universitaires de Strasbourg (HUS)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Hôpital de Hautepierre Strasbourg, Centre Hospitalier Universitaire de Nancy (CHU Nancy), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), hôpital de Poissy-Saint-Germain-en Laye, Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Hôpital de la Timone CHU - APHM (TIMONE), CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Universitaire Carémeau Nîmes (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Hospices Civils de Lyon (HCL), Observatoire Français de la Sclérose En Plaques Lyon (OFSEP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Université de Caen Normandie (UNICAEN), Normandie Université (NU), Centre d'Investigation Clinique Rennes (CIC), Université de Rennes (UR)-Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou -Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 1352-4585. |
| بيانات النشر: | CCSD SAGE Publications |
| سنة النشر: | 2025 |
| مصطلحات موضوعية: | Multiple sclerosis, Disease-modifying therapies, Epidemiology, Social inequalities, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Research grant from Eugène Devic EDMUS Foundation against MS, in partnership with the ARSEP Foundation ; International audience ; Background: We hypothesized that differences in access to disease-modifying treatments (DMTs) could explain the association between socioeconomic status and disability progression in multiple sclerosis (MS). Objective: This study aimed to analyze the association between education level and DMT use in France. Methods: All patients from OFSEP network with MS onset over 1996–2014 and aged ⩾ 25 years at onset were included. Three time-to-event outcomes were investigated using flexible parametric survival regression models: time from MS onset to first DMT (any) and to platform therapy, and time from platform therapy to switch to high-efficacy therapy. Results: Overall, 7563 patients were included (mean follow-up 12.6 ± 5.9 years). The percentages of patients aged less than 40 years at MS onset and who initiated treatment before the age of 40 years were significantly higher in the groups with a higher education level. The time-to-event outcomes showed no major difference in DMT practices according to education level, except for women who had a significantly shorter time to DMT initiation in medium to very high education level groups versus low, at 5 years from MS clinical onset. Conclusion: Our results suggest that the association between education level and MS disability progression does not solely reflect different therapeutic practices, particularly in men. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39618051; PUBMED: 39618051 |
| DOI: | 10.1177/13524585241289276 |
| الاتاحة: | https://ehesp.hal.science/hal-04826502 https://doi.org/10.1177/13524585241289276 |
| رقم الانضمام: | edsbas.7F65A1AA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/13524585241289276 |
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