Academic Journal
Role of Thyroid Deficiency on Adiponectin, Leptin, and Metabolic Status in Visceral Obesity: A Cross-Sectional Study
| العنوان: | Role of Thyroid Deficiency on Adiponectin, Leptin, and Metabolic Status in Visceral Obesity: A Cross-Sectional Study |
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| المؤلفون: | Lozanov, Lachezar, Gorcheva, Desislava, Lozanov, Bojan, Argirova, Radka, Koleva, Veselina, Kostova, Boyka, Borisov, Radoslav, Nedeva, Mariana |
| المصدر: | Hormone and Metabolic Research ; volume 49, issue 09, page 667-672 ; ISSN 0018-5043 1439-4286 |
| بيانات النشر: | Georg Thieme Verlag KG |
| سنة النشر: | 2017 |
| الوصف: | Hypothyroidism results in disturbances of metabolism influencing many regulatory systems and active molecules as adipocytokines. Objective of the study was to investigate leptin and adiponectin in patients with visceral obesity and hypothyroidism in relation to metabolic status, insulin resistance and systemic inflammation. A total of 118 patients (59 hypothyroid and 59 euthyroid) were enrolled divided into four age-matched groups according to body wеight (BMI) and thyroid function. Laboratory panel includes TSH, FT4, FT3 (CMIA), adiponectin and leptin (ELISA), IL- 6 (ECLIA), CRP, insulin, glucose, apolipoprotein B and lipoprotein (a) - Lp(a). Hypothyroid patients revealed significant positive correlations of TSH, adiponectin and Lp(a). Their medians of 10.4 mU/l, 12.5 µg/ml and 116.3 mg/l respectively were significantly higher than in euthyroid patients- 1.5 mU/l, 6.26 µg/ml and 32.0 mU/l (p < 0.0001). Leptin in both obese groups was significantly higher than in patients with normal weight. Leptin in hypothyroid patients was lower but not significant to euthyroid ones (9.7 ng/ml vs 13.4 ng/ml respectively, p = 0.16), correlated negatively to TSH and positively to CRP, IL-6, ApoB, Lp(a) and BMI. HOMA-IR and serum insulin at 120 min in OGTT were significantly higher in hypothyroid than in euthyroid patients independent of BMI (p < 0.001). Adiponectin, insulin resistance and chronic inflammation indices in hypothyroid patients correlated positively to TSH, BMI and atherogenic lipoproteins subclasses ApoB/Lp(a). Increased adiponectin in thyroid deficiency could be due to secondary resistance of adiponectin receptors or appeared as a compensatory pathogenetic factor in hypothyroidism. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1055/s-0043-115532 |
| DOI: | 10.1055/s-0043-115532.pdf |
| الاتاحة: | http://dx.doi.org/10.1055/s-0043-115532 http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0043-115532.pdf |
| رقم الانضمام: | edsbas.7F58C606 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1055/s-0043-115532 |
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