Academic Journal
Radiographic vertebral fractures develop in patients with ankylosing spondylitis during 4 years of TNF-α blocking therapy
| العنوان: | Radiographic vertebral fractures develop in patients with ankylosing spondylitis during 4 years of TNF-α blocking therapy |
|---|---|
| المؤلفون: | Maas, F., Spoorenberg, A., Brouwer, Liesbeth, Schilder, A. M., Chaudhry, R. N., Wink, F., Bootsma, H., van der Veer, E., Arends, Suzanne |
| المصدر: | Maas , F , Spoorenberg , A , Brouwer , L , Schilder , A M , Chaudhry , R N , Wink , F , Bootsma , H , van der Veer , E & Arends , S 2016 , ' Radiographic vertebral fractures develop in patients with ankylosing spondylitis during 4 years of TNF-α blocking therapy ' , Clinical and Experimental Rheumatology , vol. 34 , no. 2 , CER8295 , pp. 191-199 . < http://www.clinexprheumatol.org/abstract.asp?a=9086 > |
| سنة النشر: | 2016 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | ankylosing spondylitis, tumour necrosis factor-alpha blocking therapy, spinal fracture, incidence, bone density, BONE-MINERAL DENSITY, LONGITUDINAL OBSERVATIONAL COHORT, DISEASE-ACTIVITY, HIGH PREVALENCE, RISK, OSTEOPOROSIS, DEFORMITIES, DISCONTINUATION, COMPLICATIONS, HYPERKYPHOSIS |
| الوصف: | OBJECTIVES: To determine the prevalence and incidence of radiographic vertebral fractures in ankylosing spondylitis (AS) patients treated with TNF-α blocking therapy for 4 years and to explore the relationship with patient characteristics, clinical assessments, radiographic damage, and bone mineral density (BMD). METHODS: This study included consecutive AS patients with active disease from the Groningen Leeuwarden AS (GLAS) cohort treated with TNF-α blocking therapy for 4 years and with available thoracic and lumbar radiographs at baseline and at 4 years. Vertebral fractures were assessed by two readers (mild: ≥20-<25%, moderate: ≥25-<40%, severe: ≥40% reduction in vertebral height). RESULTS: In 27 of 105 (26%) AS patients, radiographic vertebral fractures were observed at baseline. These patients were significantly older, had larger occiput-to-wall distance, and more spinal radiographic damage. During 4 years of TNF-α blocking therapy, 21 (20%) patients developed at least one new fracture. Older age, smoking, higher BASFI, low lumbar spine BMD (Z-score ≤-2), presence of moderate vertebral fractures, and use of anti-osteoporotic treatment at baseline were associated with the development of new fractures. Most fractures were mild and occurred in the thoracic spine. The improvement in lateral spinal mobility and lumbar spine BMD during treatment was significantly less in patients with new fractures (median change of 0.8 vs. 2.8 cm and 0.3 vs. 0.8 Z-score, respectively). CONCLUSIONS: The prevalence of radiographic vertebral fractures was high in AS patients with active disease. Although clinical assessments and BMD improved significantly, new vertebral fractures still developed during 4 years of TNF-α blocking therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الاتاحة: | https://hdl.handle.net/11370/0f4847b4-7d9d-4d90-88d8-175c590ba6a8 https://research.rug.nl/en/publications/0f4847b4-7d9d-4d90-88d8-175c590ba6a8 https://pure.rug.nl/ws/files/201870684/4._Maas_et_al._Clin_Exp_Rheum_2016_VF_4_years_TNFi_.pdf http://www.clinexprheumatol.org/abstract.asp?a=9086 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7F4C9506 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |