Academic Journal
A Preliminary Evaluation of the Pro-Chondrogenic Potential of 3D-Bioprinted Poly(ester Urea) Scaffolds
| العنوان: | A Preliminary Evaluation of the Pro-Chondrogenic Potential of 3D-Bioprinted Poly(ester Urea) Scaffolds |
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| المؤلفون: | Moxon, Samuel R., Ferreira, Miguel J. S., Santos, Patrícia dos, Popa, Bogdan, Gloria, Antonio, Katsarava, Ramaz, Tugushi, David, Serra, Arménio C., Hooper, Nigel M., Kimber, Susan J., Fonseca, Ana C., Domingos, Marco A. N. |
| بيانات النشر: | MDPI |
| سنة النشر: | 2020 |
| المجموعة: | Universidade de Coimbra: Estudo Geral |
| مصطلحات موضوعية: | 3D bioprinting, cartilage repair, tissue engineering, poly(ester urea), scaffold design |
| الوصف: | Degeneration of articular cartilage (AC) is a common healthcare issue that can result in significantly impaired function and mobility for affected patients. The avascular nature of the tissue strongly burdens its regenerative capacity contributing to the development of more serious conditions such as osteoarthritis. Recent advances in bioprinting have prompted the development of alternative tissue engineering therapies for the generation of AC. Particular interest has been dedicated to scaffold-based strategies where 3D substrates are used to guide cellular function and tissue ingrowth. Despite its extensive use in bioprinting, the application of polycaprolactone (PCL) in AC is, however, restricted by properties that inhibit pro-chondrogenic cell phenotypes. This study proposes the use of a new bioprintable poly(ester urea) (PEU) material as an alternative to PCL for the generation of an in vitro model of early chondrogenesis. The polymer was successfully printed into 3D constructs displaying adequate substrate stiffness and increased hydrophilicity compared to PCL. Human chondrocytes cultured on the scaffolds exhibited higher cell viability and improved chondrogenic phenotype with upregulation of genes associated with type II collagen and aggrecan synthesis. Bioprinted PEU scaffolds could, therefore, provide a potential platform for the fabrication of bespoke, pro-chondrogenic tissue engineering constructs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2073-4360 |
| Relation: | #PLACEHOLDER_PARENT_METADATA_VALUE#; Henry Royce Institute for Advanced Materials, funded through EPSRC grants EP/R00661X/1, EP/S019367/1, EP/P025021/1 and EP/P025498/1; University of Manchester; EPSRC-MRC sponsered Miguel Ferreira’s PhD studentship in Regenerative Medicine; http://hdl.handle.net/10316/106631 |
| DOI: | 10.3390/polym12071478 |
| الاتاحة: | http://hdl.handle.net/10316/106631 https://doi.org/10.3390/polym12071478 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7F4C018D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20734360 |
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| DOI: | 10.3390/polym12071478 |