Academic Journal
Pre-existing helminth infection impairs the efficacy of adjuvanted influenza vaccination in mice
| العنوان: | Pre-existing helminth infection impairs the efficacy of adjuvanted influenza vaccination in mice |
|---|---|
| المؤلفون: | Hartmann, Wiebke, Brunn, Marie-Luise, Stetter, Nadine, Gabriel, Gülsah, Breloer, Minka |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | article, ddc:630, Hochschulbibliographie allgemein, Verzeichnis wissenschaftlicher Veröffentlichungen, Animals, Humans, Mice, Helminths, Influenza A virus, Orthomyxoviridae Infections, Helminthiasis, Weight Loss, Influenza Vaccines, Adjuvants, Immunologic, Antibodies, Viral, Vaccination, Influenza, Human, H1N1 Subtype, Pandemics, COVID-19 |
| Time: | 2022 |
| الوصف: | The world health organization estimates that more than a quarter of the human population is infected with parasitic worms that are called helminths. Many helminths suppress the immune system of their hosts to prolong their survival. This helminth-induced immunosuppression "spills over" to unrelated antigens and can suppress the immune response to vaccination against other pathogens. Indeed, several human studies have reported a negative correlation between helminth infections and responses to vaccinations. Using mice that are infected with the parasitic nematode Litomosoides sigmodontis as a model for chronic human filarial infections, we reported previously that concurrent helminth infection impaired the vaccination-induced protection against the human pathogenic 2009 pandemic H1N1 influenza A virus (2009 pH1N1). Vaccinated, helminth-infected mice produced less neutralizing, influenza-specific antibodies than vaccinated naïve control mice. Consequently helminth-infected and vaccinated mice were not protected against a challenge infection with influenza virus but displayed high virus burden in the lung and a transient weight loss. In the current study we tried to improve the vaccination efficacy using vaccines that are licensed for humans. We either introduced a prime-boost vaccination regimen using the non-adjuvanted anti-influenza vaccine Begripal or employed the adjuvanted influenza vaccine Fluad. Although both strategies elevated the production of influenza-specific antibodies and protected mice from the transient weight loss that is caused by an influenza challenge infection, sterile immunity was not achieved. Helminth-infected vaccinated mice still had high virus burden in the lung while non-helminth-infected vaccinated mice rapidly cleared the virus. In summary we demonstrate that basic improvements of influenza vaccination regimen are not sufficient to confer sterile immunity on the background of helminth-induced immunosuppression, despite amelioration of pathology i.e. weight loss. Our findings ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | PLoS ONE -- http://www.bibliothek.uni-regensburg.de/ezeit/?2267670 -- http://www.plosone.org/home.action -- https://journals.plos.org/plosone/ -- https://www.ncbi.nlm.nih.gov/pmc/journals/440/ -- 1932-6203 -- 2267670-3 -- PLOS ONE; https://doi.org/10.1371/journal.pone.0266456; https://elib.tiho-hannover.de/receive/tiho_mods_00009003; https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00002162/journal.pone.0266456.pdf; https://europepmc.org/articles/PMC8970517; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0266456 |
| DOI: | 10.1371/journal.pone.0266456 |
| الاتاحة: | https://doi.org/10.1371/journal.pone.0266456 https://elib.tiho-hannover.de/receive/tiho_mods_00009003 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00002162/journal.pone.0266456.pdf https://europepmc.org/articles/PMC8970517 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0266456 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7F45CA9B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0266456 |
|---|