Academic Journal

Twenty-Four-Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals.

التفاصيل البيبلوغرافية
العنوان: Twenty-Four-Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals.
المؤلفون: Weber, Thomas, Protogerou, Athanase D, Agharazii, Mohsen, Argyris, Antonis, Aoun Bahous, Sola, Banegas, Jose R, Binder, Ronald K, Blacher, Jacques, Araujo Brandao, Andréa, Cruz, Juan J, Danninger, Kathrin, Giannatasio, Cristina, Graciani, Auxiliadora, Hametner, Bernhard, Jankowski, Piotr, Li, Yan, Maloberti, Alessandro, Mayer, Christopher C, McDonnell, Barry J, McEniery, Carmel M, Antonio Mota Gomes, Marco, Machado Gomes, Annelise, Lorenza Muiesan, Maria, Nemcsik, Janos, Paini, Anna, Rodilla, Enrique, Schutte, Aletta E, Sfikakis, Petros P, Terentes-Printzios, Dimitrios, Vallée, Alexandre, Vlachopoulos, Charalambos, Ware, Lisa, Wilkinson, Ian, Zweiker, Robert, Sharman, James E, Wassertheurer, Siegfried, International Academic 24-Hour Ambulatory Aortic Blood Pressure Consortium (i24abc.org)
المصدر: essn: 1524-4563 ; nlmid: 7906255
بيانات النشر: Ovid Technologies (Wolters Kluwer Health)
//dx.doi.org/10.1161/hypertensionaha.121.17765
Hypertension
سنة النشر: 2022
المجموعة: Apollo - University of Cambridge Repository
مصطلحات موضوعية: arterial pressure, blood pressure, heart rate, hypertension, Adolescent, Adult, Aged, 80 and over, Blood Pressure Determination, Brachial Artery, Circadian Rhythm, Female, Humans, Male, Middle Aged, Reference Values, Young Adult
الوصف: Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18-94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBPMAP/DBPcal), or bSBP/diastolic blood pressure (cSBPSBP/DBPcal), and a validated transfer function, resulting in 144 509 valid brachial and 130 804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBPMAP/DBPcal were 128, 128, and 125 mm Hg and 115, 117, and 107 mm Hg for cSBPSBP/DBPcal, respectively. We pragmatically propose as upper normal limit for 24-hour cSBPMAP/DBPcal 135 mm Hg and for 24-hour cSBPSBP/DBPcal 120 mm Hg. bSBP dipping (nighttime-daytime/daytime SBP) was -10.6 % in young participants and decreased with increasing age. Central SBPSBP/DBPcal dipping was less pronounced (-8.7% in young participants). In contrast, cSBPMAP/DBPcal dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
Relation: https://www.repository.cam.ac.uk/handle/1810/332329
DOI: 10.17863/CAM.79775
الاتاحة: https://www.repository.cam.ac.uk/handle/1810/332329
https://doi.org/10.17863/CAM.79775
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0/
رقم الانضمام: edsbas.7F3C6F4D
قاعدة البيانات: BASE