Academic Journal
The anti-viral dynamin family member MxB participates in mitochondrial integrity
| العنوان: | The anti-viral dynamin family member MxB participates in mitochondrial integrity |
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| المؤلفون: | Cao, Hong, Krueger, E. W., Chen, Jing, Drizyte-Miller, Kristina, Schulz, Mary E., McNiven, Mark A. |
| المساهمون: | U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases |
| المصدر: | Nature Communications ; volume 11, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2020 |
| الوصف: | The membrane deforming dynamin family members MxA and MxB are large GTPases that convey resistance to a variety of infectious viruses. During viral infection, Mx proteins are known to show markedly increased expression via an interferon-responsive promoter to associate with nuclear pores. In this study we report that MxB is an inner mitochondrial membrane GTPase that plays an important role in the morphology and function of this organelle. Expression of mutant MxB or siRNA knockdown of MxB leads to fragmented mitochondria with disrupted inner membranes that are unable to maintain a proton gradient, while expelling their nucleoid-based genome into the cytoplasm. These findings implicate a dynamin family member in mitochondrial-based changes frequently observed during an interferon-based, anti-viral response. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-020-14727-w |
| الاتاحة: | http://dx.doi.org/10.1038/s41467-020-14727-w https://www.nature.com/articles/s41467-020-14727-w.pdf https://www.nature.com/articles/s41467-020-14727-w |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.7F39C19B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-020-14727-w |
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