Academic Journal
Structural and functional diversity of ferredoxin-NADP+ reductases
| العنوان: | Structural and functional diversity of ferredoxin-NADP+ reductases |
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| المؤلفون: | A. Aliverti, V. Pandini, A. Pennati, M. de Rosa, G. Zanetti |
| المساهمون: | A. Aliverti, V. Pandini, A. Pennati, M. de Rosa, G. Zanetti |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2008 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | flavoprotein, FAD, NADP, photosynthesi, induced fit, electron transfer, Apicomplexa, Plasmodium falciparum, malaria, Settore BIO/10 - Biochimica |
| الوصف: | Although all ferredoxin-NADP+ reductases (FNRs) catalyze the same reaction, i.e. the transfer of reducing equivalents between NADP(H) and ferredoxin, they belong to two unrelated families of proteins: the plant-type and the glutathione reductase-type of FNRs. Aim of this review is to provide a general classification scheme for these enzymes, to be used as a framework for the comparison of their properties. Furthermore, we report on some recent findings, which significantly increased the understanding of the structure–function relationships of FNRs, i.e. the ability of adrenodoxin reductase and its homologs to catalyze the oxidation of NADP+ to its 4-oxo derivative, and the properties of plant-type FNRs from non-photosynthetic organisms. Plant-type FNRs from bacteria and Apicomplexan parasites provide examples of novel ways of FAD- and NADP(H)-binding. The recent characterization of an FNR from Plasmodium falciparum brings these enzymes into the field of drug design. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/18307973; info:eu-repo/semantics/altIdentifier/wos/WOS:000256691200007; Trends in Enzymology Conference; volume:474; issue:2; firstpage:283; lastpage:291; numberofpages:9; journal:ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; http://hdl.handle.net/2434/41439; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-44549083194 |
| DOI: | 10.1016/j.abb.2008.02.014 |
| الاتاحة: | http://hdl.handle.net/2434/41439 https://doi.org/10.1016/j.abb.2008.02.014 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7F26C755 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.abb.2008.02.014 |
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