Academic Journal
Trelagliptin succinate: DPP-4 inhibitor to improve insulin resistance in adipocytes
| العنوان: | Trelagliptin succinate: DPP-4 inhibitor to improve insulin resistance in adipocytes |
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| المؤلفون: | Zhenhua Liu, Lanting Xu, Meimei Xing, Xiaojie Xu, Jinfeng Wei, Jinmei Wang, Wenyi Kang |
| المصدر: | Biomedicine & Pharmacotherapy, Vol 125, Iss , Pp 109952- (2020) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2020 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Trelagliptin succinate, Insulin resistance, Adipokines, Glucose intake, PI-3K/Akt, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Trelagliptin inhibits the enzyme dipeptidyl-4 (DPP-4) to treat type 2 diabetes and it may possess the potential to improve insulin resistance. However, the molecular mechanism is not known. In this study, the effect of trelagliptin succinate in improving insulin resistance was investigated. The differentiation system of 3T3-L1 mouse preadipocytes was used to determine the content of adipokines and the content of GLUT4 in the outer membrane. The expression of AKT, P-AKT, IRS-1 and P-IRS-1 in differentiated 3T3-L1 adipocytes was determined by western blotting. Our results demonstrated that trelagliptin succinate increased the expression of AKT, P-AKT, IRS-1 and P-IRS-1 in the PI-3K/AKT insulin signaling pathway. These events promote the trans-membrane function of GLUT4 and concomitant glucose intake in adipocytes. In addition, the secretion of free fatty acids and resistin were decreased. In conclusion, our study suggested that trelagliptin succinate improved insulin resistance in adipocytes via regulation of PI-3K/AKT/GLUT4 insulin signaling pathway. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0753-3322 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0753332220301426; https://doaj.org/toc/0753-3322; https://doaj.org/article/5591d0f231ee4effb6844eb88b350b11 |
| DOI: | 10.1016/j.biopha.2020.109952 |
| الاتاحة: | https://doi.org/10.1016/j.biopha.2020.109952 https://doaj.org/article/5591d0f231ee4effb6844eb88b350b11 |
| رقم الانضمام: | edsbas.7F221EF7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 07533322 |
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| DOI: | 10.1016/j.biopha.2020.109952 |