Academic Journal
How to identify subgroups in longitudinal clinical data: treatment response patterns in patients with a shortened dental arch.
| العنوان: | How to identify subgroups in longitudinal clinical data: treatment response patterns in patients with a shortened dental arch. |
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| المؤلفون: | Schierz, Oliver, Lee, Chi Hyun, John, Mike T., Rauch, Angelika, Reissmann, Daniel R., Marré, Birgit, Luthardt, Ralph G., Rudolph, Heike, Mundt, Torsten, Hannak, Wolfgang, Kohal, Ralf-Joachim, Heydecke, Guido, Kern, Matthias, Hartmann, Sinsa, Böning, Klaus W., Boldt, Julian, Stark, Helmut, Edelhoff, Daniel, Wöstmann, Bernd, Wolfart, Stefan, Jahn, Florentine, Walter, Michael Horst |
| المصدر: | The journal of evidence based dental practice. - 23, 1 (2023) , 101794, ISSN: 1532-3390 |
| سنة النشر: | 2023 |
| المجموعة: | University of Freiburg: FreiDok |
| الوصف: | Background When dental patients seek care, treatments are not always successful,that is patients' oral health problems are not always eliminated or substantially reduced. Identifying these patients (treatment non-responders) is essential for clinical decision-making. Group-based trajectory modeling (GBTM) is rarely used in dentistry, but a promising statistical technique to identify non-responders in particular and clinical distinct patient groups in general in longitudinal data sets. Aim Using group-based trajectory modeling, this study aimed to demonstrate how to identify oral health-related quality of life (OHRQoL) treatment response patterns by the example of patients with a shortened dental arch (SDA). Methods This paper is a secondary data analysis of a randomized controlled clinical trial. In this trial SDA patients received partial removable dental prostheses replacing missing teeth up to the first molars (N = 79) either or the dental arch ended with the second premolar that was present or replaced by a cantilever fixed dental prosthesis (N = 71). Up to ten follow-up examinations (1-2, 6, 12, 24, 36, 48, 60, 96, 120, and 180 months post-treatment) continued for 15 years. The outcome OHRQoL was assessed with the 49-item Oral Health Impact Profile (OHIP). Exploratory GBTM was performed to identify treatment response patterns. Results Two response patterns could be identified - "responders" and "non-responders." Responders’ OHRQoL improved substantially and stayed primarily stable over the 15 years. Non-responders’ OHRQoL did not improve considerably over time or worsened. While the SDA treatments were not related to the 2 response patterns, higher levels of functional, pain-related, psychological impairment in particular, and severely impaired OHRQoL in general predicted a non-responding OHRQoL pattern after treatment. Supplementary, a 3 pattern approach has been evaluated. Conclusions Clustering patients according to certain longitudinal characteristics after treatment is generally important, but ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| Relation: | https://freidok.uni-freiburg.de/data/231111 |
| DOI: | 10.1016/j.jebdp.2022.101794 |
| الاتاحة: | https://freidok.uni-freiburg.de/data/231111 https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2311114 https://doi.org/10.1016/j.jebdp.2022.101794 https://freidok.uni-freiburg.de/dnb/download/231111 |
| Rights: | free |
| رقم الانضمام: | edsbas.7F1D20B2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jebdp.2022.101794 |
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