Academic Journal
Outcome and management of patients with hepatocellular carcinoma who achieved complete response to immunotherapy-based systemic therapy
| العنوان: | Outcome and management of patients with hepatocellular carcinoma who achieved complete response to immunotherapy-based systemic therapy |
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| المؤلفون: | Scheiner B., Kang B., Balcar L., Radu I. -P., Reiter F. P., Adzic G., Guo J., Gao X., Yuan X., Cheng L., Gorgulho J., Schultheiss M., Peeters F., Hucke F., Ben Khaled N., Piseddu I., Philipp A., Sinner F., D'Alessio A., Pomej K., Saborowski A., Bathon M., Schwacha-Eipper B., Zarka V., Lampichler K., Nishida N., Lee P. -C., Krall A., Saeed A., Himmelsbach V., Tesini G., Huang Y. -H., Vivaldi C., Masi G., Vogel A., Schulze K., Trauner M., Djanani A., Stauber R., Kudo M., Parikh N. D., Dufour J. -F., Prejac J., Geier A., Bengsch B., von Felden J., Venerito M., Weinmann A., Peck-Radosavljevic M., Finkelmeier F., Dekervel J., Ji F., Wang H. -W., Rimassa L., Pinato D. J., Bouattour M., Chon H. J., Pinter M. |
| المساهمون: | Scheiner, B., Kang, B., Balcar, L., Radu, I. -P., Reiter, F. P., Adzic, G., Guo, J., Gao, X., Yuan, X., Cheng, L., Gorgulho, J., Schultheiss, M., Peeters, F., Hucke, F., Ben Khaled, N., Piseddu, I., Philipp, A., Sinner, F., D'Alessio, A., Pomej, K., Saborowski, A., Bathon, M., Schwacha-Eipper, B., Zarka, V., Lampichler, K., Nishida, N., Lee, P. -C., Krall, A., Saeed, A., Himmelsbach, V., Tesini, G., Huang, Y. -H., Vivaldi, C., Masi, G., Vogel, A., Schulze, K., Trauner, M., Djanani, A., Stauber, R., Kudo, M., Parikh, N. D., Dufour, J. -F., Prejac, J., Geier, A., Bengsch, B., von Felden, J., Venerito, M., Weinmann, A., Peck-Radosavljevic, M., Finkelmeier, F., Dekervel, J., Ji, F., Wang, H. -W., Rimassa, L., Pinato, D. J., Bouattour, M., Chon, H. J., Pinter, M. |
| سنة النشر: | 2024 |
| المجموعة: | Università degli Studi del Piemonte Orientale: CINECA IRIS |
| مصطلحات موضوعية: | immune checkpoint inhibitor, liver cancer, RECIST, systemic therapy |
| الوصف: | Background&Aims: The outcome of patients with hepatocellular carcinoma (HCC) who achieved complete response (CR) to immune-checkpoint-inhibitor (ICI)-based systemic therapies is unclear. Approach&Results: Retrospective study of patients with HCC who had CR according to mRECIST to ICI-based systemic therapies from 28 centers in Asia, Europe, and the United States. Of 3933 patients with HCC treated with ICI-based non-curative systemic therapies, 174 (4.4%) achieved CR according to mRECIST (CR-mRECIST) and 97 (2.5%) had CR according to RECISTv1.1 (CR-RECISTv1.1) as well. The mean age of the total cohort (male, 85%; BCLC-C, 70%) was 65.9±9.8 years. The majority (83%) received ICI-based combination therapies. Median follow-up was 32.2 (95%CI, 29.9-34.4) months. One- and 3-year overall survival (OS) rates were 98% and 86%. One- and 3-year recurrence-free survival (RFS) rates were excellent in patients with CR-mRECIST-only and CR-RECISTv1.1 (78% and 55%; 70% and 42%). Among patients who discontinued ICIs for reasons other than recurrence, those who received immunotherapy for ≥6 months after first mRECIST CR had a longer RFS than those who discontinued immunotherapy earlier (p=0.008). Of 9 patients who underwent curative surgical conversion therapy, 8 (89%) had pathological CR (CRRECISTv1.1, n= 2/2; CR-mRECIST-only, n= 6/7). Conclusion: OS and RFS of patients with CR-mRECIST-only and CR-RECISTv1.1 were excellent, and 6 of 7 patients with CR-mRECIST-only who underwent surgical conversion therapy had pathological CR. Despite potential limitations, these findings support the use of mRECIST in the context of immunotherapy for clinical decision-making. When considering ICI discontinuation, treatment for at least 6 months beyond CR seems advisable. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39643944; info:eu-repo/semantics/altIdentifier/wos/WOS:001371233600001; journal:HEPATOLOGY; https://hdl.handle.net/11579/202273 |
| DOI: | 10.1097/HEP.0000000000001163 |
| الاتاحة: | https://hdl.handle.net/11579/202273 https://doi.org/10.1097/HEP.0000000000001163 |
| رقم الانضمام: | edsbas.7F0BDAB8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/HEP.0000000000001163 |
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