Academic Journal
Long-Term Evaluation of Gadolinium Retention in Rat Brain After Single Injection of a Clinically Relevant Dose of Gadolinium-Based Contrast Agents
| العنوان: | Long-Term Evaluation of Gadolinium Retention in Rat Brain After Single Injection of a Clinically Relevant Dose of Gadolinium-Based Contrast Agents |
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| المؤلفون: | Strzeminska, Izabela, Factor, Cécile, Robert, Philippe, Grindel, Anne-Laure, Comby, Pierre-Olivier, Szpunar, Joanna, Corot, Claire, Lobinski, Ryszard |
| المساهمون: | Laboratoire Guerbet / Guerbet Research, Adhésion et Inflammation (LAI), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 0020-9996 ; Investigative Radiology ; https://univ-pau.hal.science/hal-02481979 ; Investigative Radiology, 2020, 55 (3), pp.138-143. ⟨10.1097/RLI.0000000000000623⟩. |
| بيانات النشر: | HAL CCSD Lippincott, Williams & Wilkins |
| سنة النشر: | 2020 |
| المجموعة: | HAL e2s UPPA (Université de Pau et des Pays de l'Adour) |
| مصطلحات موضوعية: | gadolinium-based contrast agent, cerebellum, gadolinium species, gadolinium retention, gadodiamide, gadobenate, gadoterate, gadoterate (Invest Radiol 2020, 55: 138-143), [CHIM.POLY]Chemical Sciences/Polymers, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry |
| الوصف: | International audience ; The aim of this study was to investigate the presence and chemical forms of residual gadolinium (Gd) in rat brain after a single dose of Gd-based contrast agent. METHODS: Four groups of healthy rats (2 sacrifice time-points, n = 10/group, 80 rats in total) were randomized to receive a single intravenous injection of 1 of the 3 Gd-based contrast agents (GBCAs) (gadoterate meglumine, gadobenate dimeglumine, or gadodiamide) or the same volume of 0.9% saline solution. The injected concentration was 0.6 mmol/kg, corresponding to a concentration of 0.1 mmol/kg in humans after body surface normalization between rats and humans (according to the US Food and Drug Administration recommendations). Animals were sacrificed at 2 washout times: 1 (M1) and 5 (M5) months after the injection. Total Gd concentrations were determined in cerebellum by inductively coupled plasma mass spectrometry. Gadolinium speciation was analyzed by size-exclusion chromatography coupled to inductively coupled plasma mass spectrometry after extraction from cerebellum. RESULTS: A single injection of a clinically relevant dose of GBCA resulted in the detectable presence of Gd in the cerebellum 1 and 5 months after injection. The cerebellar total Gd concentrations after administration of the least stable GBCA (gadodiamide) were significantly higher at both time-points (M1: 0.280 ± 0.060 nmol/g; M5: 0.193 ± 0.023 nmol/g) than those observed for macrocyclic gadoterate (M1: 0.019 ± 0.004 nmol/g, M5: 0.004 ± 0.002 nmol/g; P < 0.0001). Gadolinium concentrations after injection of gadobenate were significantly lower at both time-points (M1: 0.093 ± 0.020 nmol/g; M5: 0.067 ± 0.013 nmol/g; P < 0.05) than the Gd concentration measured after injection of gadodiamide. At the 5-month time-point, the Gd concentration in the gadoterate group was also significantly lower than the Gd concentration in the gadobenate group (P < 0.05). Gadolinium speciation analysis of the water-soluble fraction showed that, after injection of the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-02481979; https://univ-pau.hal.science/hal-02481979; https://univ-pau.hal.science/hal-02481979/document; https://univ-pau.hal.science/hal-02481979/file/rli-55-138.pdf |
| DOI: | 10.1097/RLI.0000000000000623 |
| الاتاحة: | https://univ-pau.hal.science/hal-02481979 https://univ-pau.hal.science/hal-02481979/document https://univ-pau.hal.science/hal-02481979/file/rli-55-138.pdf https://doi.org/10.1097/RLI.0000000000000623 |
| Rights: | http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.7F08E14 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/RLI.0000000000000623 |
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