Academic Journal
MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes
| العنوان: | MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes |
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| المؤلفون: | Xiaomin Zhang, Gohar Azhar, Emmanuel D. Williams, Steven C. Rogers, Jeanne Y. Wei |
| المصدر: | BioMed Research International, Vol 2015 (2015) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2015 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine |
| الوصف: | The microRNAs and microRNA clusters have been implicated in normal cardiac development and also disease, including cardiac hypertrophy, cardiomyopathy, heart failure, and arrhythmias. Since a microRNA cluster has from two to dozens of microRNAs, the expression of a microRNA cluster could have a substantial impact on its target genes. In the present study, the configuration and distribution of microRNA clusters in the mouse genome were examined at various inter-microRNA distances. Three important microRNA clusters that are significantly impacted during adult cardiac aging, the miR-17-92, miR-106a-363, and miR-106b-25, were also examined in terms of their genomic location, RNA transcript character, sequence homology, and their relationship with the corresponding microRNA families. Multiple microRNAs derived from the three clusters potentially target various protein components of the cdc42-SRF signaling pathway, which regulates cytoskeleton dynamics associated with cardiac structure and function. The data indicate that aging impacted the expression of both guide and passenger strands of the microRNA clusters; nutrient stress also affected the expression of the three microRNA clusters. The miR-17-92, miR-106a-363, and miR-106b-25 clusters are likely to impact the Cdc42-SRF signaling pathway and thereby affect cardiac morphology and function during pathological conditions and the aging process. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2314-6133 2314-6141 |
| Relation: | http://dx.doi.org/10.1155/2015/732397; https://doaj.org/toc/2314-6133; https://doaj.org/toc/2314-6141; https://doaj.org/article/7d2ea036541c4c9d98acd433e51b21bb |
| DOI: | 10.1155/2015/732397 |
| الاتاحة: | https://doi.org/10.1155/2015/732397 https://doaj.org/article/7d2ea036541c4c9d98acd433e51b21bb |
| رقم الانضمام: | edsbas.7ECE1EB6 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23146133 23146141 |
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| DOI: | 10.1155/2015/732397 |