Academic Journal
HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features.
| العنوان: | HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features. |
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| المؤلفون: | Guerrero, J., Trias, I., Veloza, L., Del Pino, M., Garcia, A., Marimon, L., Diaz-Mercedes, S., Rodrigo-Calvo, M.T., Alós, S., Ajami, T., Parra-Medina, R., Martinez, A., Reig, O., Ribal, M.J., Corral-Molina, J.M., Ordi, J., Ribera-Cortada, I., Rakislova, N. |
| المصدر: | The American journal of surgical pathology, vol. 46, no. 8, pp. 1071-1077 |
| سنة النشر: | 2022 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Aged, 80 and over, Carcinoma in Situ/pathology, Cyclin-Dependent Kinase Inhibitor p16/metabolism, Humans, Male, Papillomaviridae/genetics, Papillomavirus Infections/pathology, Penile Neoplasms/pathology, Skin Neoplasms/pathology, Squamous Intraepithelial Lesions/pathology, Tumor Suppressor Protein p53/metabolism |
| الوصف: | Most human papillomavirus (HPV)-independent penile squamous cell carcinomas (PSCCs) originate from an intraepithelial precursor called differentiated penile intraepithelial neoplasia, characterized by atypia limited to the basal layer with marked superficial maturation. Previous studies in vulvar cancer, which has a similar dual etiopathogenesis, have shown that about one fifth of HPV-independent precursors are morphologically indistinguishable from high-grade squamous intraepithelial lesions (HSILs), the precursor of HPV-asssociated carcinomas. However, such lesions have not been described in PSCC. From 2000 to 2021, 55 surgical specimens of PSCC were identified. In all cases, thorough morphologic evaluation, HPV DNA detection, and p16, p53, and Ki-67 immunohistochemical (IHC) staining was performed. HPV-independent status was assigned based on both negative results for p16 IHC and HPV DNA. Thirty-six of the 55 PSCC (65%) were HPV-independent. An intraepithelial precursor was identified in 26/36 cases (72%). Five of them (19%) had basaloid features, morphologically indistinguishable from HPV-associated HSIL. The median age of the 5 patients was 74 years (range: 67 to 83 y). All 5 cases were p16 and DNA HPV-negative. Immunohistochemically, 3 cases showed an abnormal p53 pattern, and 2 showed wild-type p53 staining. The associated invasive carcinoma was basaloid in 4 cases and the usual (keratinizing) type in 1. In conclusion, a small proportion of HPV-independent PSCC may arise on adjacent intraepithelial lesions morphologically identical to HPV-associated HSIL. This unusual histologic pattern has not been previously characterized in detail in PSCC. p16 IHC is a valuable tool to identify these lesions and differentiate them from HPV-associated HSIL. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35297786; info:eu-repo/semantics/altIdentifier/eissn/1532-0979; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_4B41573043498; https://serval.unil.ch/notice/serval:BIB_4B4157304349; https://serval.unil.ch/resource/serval:BIB_4B4157304349.P001/REF.pdf |
| DOI: | 10.1097/PAS.0000000000001885 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_4B4157304349 https://doi.org/10.1097/PAS.0000000000001885 https://serval.unil.ch/resource/serval:BIB_4B4157304349.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4B41573043498 |
| Rights: | info:eu-repo/semantics/openAccess ; CC BY-NC-ND 4.0 ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.7EB5CF34 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/PAS.0000000000001885 |
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