Academic Journal
Evaluation of APOE Genotype and Vascular Risk Factors As Prognostic and Risk Factors for Alzheimer’s Disease and Their Influence On Age of Symptoms Onset
| العنوان: | Evaluation of APOE Genotype and Vascular Risk Factors As Prognostic and Risk Factors for Alzheimer’s Disease and Their Influence On Age of Symptoms Onset |
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| المؤلفون: | Novotni, Gabriela, Jakimovska, Milena, Plaseska-Karanfilska, Dijana, Tanovska, Nikolina, Kuzmanovski, I, Aleksovski, Vasko, Karanfilovik, Katerina, Dolnenec-Baneva, Natalija, Stankovic, Marijana, Milutinovikj, Milosh, Iloski, Svetlana, Isjanovska, Rozalinda, Blazevska-Stoilkovska, Biljana, Duma, Aleksej, Novotni, A |
| بيانات النشر: | Scientific foundation SPIROSKI |
| سنة النشر: | 2019 |
| الوصف: | BACKGROUND: Alzheimer’s disease (AD), the most common cause of dementia, is evolving to become a threatening epidemy of the 21st century. Only 21% of the predicted number of AD patients in Macedonia have been diagnosed and treated, which means that almost 80% are underdiagnosed or misdiagnosed. Apolipoprotein E gene (APOE) is recognised as the strongest genetic risk factor for sporadic AD. Whether and when Alzheimer’s disease develops, depends on the very complex interaction between genetic and modifiable risk factors. It has been known that vascular factors like hypertension, diabetes mellitus, hypercholesterolemia and obesity increase the risk of developing both AD, vascular dementia and mixed AD and vascular pathology AIM: This study aims to evaluate the influence of APOEε4 allele presence and modifiable vascular risk factors (hypertension, diabetes mellitus and dyslipidemia) as prognostic and risk factors for AD and their influence on the age of onset of AD symptoms among 144 AD patients from Macedonia. MATERIAL AND METHODS: Study group of a total of 144 patients diagnosed with AD was evaluated. APOE genotyping was performed using APOE haplotype-specific sequence specific-primer (SSP)-PCR (Polymerase Chain Reaction) methodology. The non-standardized questionnaire was used to obtain information about demographics, lifestyle and modifiable risk factors that could influence disease onset and phenotype. RESULTS: Statistically significant association was found between the presences of APOEε4 allele in AD group versus controls. The presence of APOEε4 allele increases the risk of developing AD in a 3-fold manner. The average age of disease onset in the ε4 carrier group was 67.2 ± 8.3 and in the ε4 non-carrier group 69.7 ± 9.4. This confirms that the presence of APOEε4 allele shifts towards earlier disease onset, though the difference is not statistically significant. Out of the vascular risk factors, only hypertension was significantly associated with earlier AD onset. Out of total 144 patients, in 22.9% the first ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Open Access Macedonian Journal of Medical Sciences; https://spiroski.migration.publicknowledgeproject.org/index.php/mjms/article/download/oamjms.2019.166/2985; https://spiroski.migration.publicknowledgeproject.org/index.php/mjms/article/download/oamjms.2019.166/2914 |
| DOI: | 10.3889/oamjms.2019.166 |
| الاتاحة: | https://doi.org/10.3889/oamjms.2019.166 https://spiroski.migration.publicknowledgeproject.org/index.php/mjms/article/download/oamjms.2019.166/2985 https://spiroski.migration.publicknowledgeproject.org/index.php/mjms/article/download/oamjms.2019.166/2914 |
| رقم الانضمام: | edsbas.7EA1743 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3889/oamjms.2019.166 |
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