Academic Journal
Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination
| العنوان: | Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination |
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| المؤلفون: | Elias, George, Meysman, Pieter, Bartholomeus, Esther, De Neuter, Nicolas, Keersmaekers, Nina, Suls, Arvid, Jansens, Hilde, Souquette, Aisha, De Reu, Hans, Emonds, Marie-Paule, Smits, Evelien, Lion, Eva, Thomas, Paul G., Mortier, Geert, van Damme, Pierre, Beutels, Philippe, Laukens, Kris, Van Tendeloo, Vigor, Ogunjimi, Benson |
| المصدر: | 2050-084X ; eLife |
| سنة النشر: | 2022 |
| المجموعة: | IRUA - Institutional Repository van de Universiteit Antwerpen |
| مصطلحات موضوعية: | Biology, Human medicine |
| الوصف: | Antigen recognition through the T cell receptor (TCR) alpha beta heterodimer is one of the primary determinants of the adaptive immune response. Vaccines activate naive T cells with high specificity to expand and differentiate into memory T cells. However, antigen-specific memory CD4 T cells exist in unexposed antigen-naive hosts. In this study, we use high-throughput sequencing of memory CD4 TCR beta repertoire and machine learning to show that individuals with preexisting vaccine-reactive memory CD4 T cell clonotypes elicited earlier and higher antibody titers and mounted a more robust CD4 T cell response to hepatitis B vaccine. In addition, integration of TCR beta sequence patterns into a hepatitis B epitope-specific annotation model can predict which individuals will have an early and more vigorous vaccine-elicited immunity. Thus, the presence of preexisting memory T cell clonotypes has a significant impact on immunity and can be used to predict immune responses to vaccination. eLife digest Immune cells called CD4 T cells help the body build immunity to infections caused by bacteria and viruses, or after vaccination. Receptor proteins on the outside of the cells recognize pathogens, foreign molecules called antigens, or vaccine antigens. Vaccine antigens are usually inactivated bacteria or viruses, or fragments of these pathogens. After recognizing an antigen, CD4 T cells develop into memory CD4 T cells ready to defend against future infections with the pathogen. People who have never been exposed to a pathogen, or have never been vaccinated against it, may nevertheless have preexisting memory cells ready to defend against it. This happens because CD4 T cells can recognize multiple targets, which enables the immune system to be ready to defend against both new and familiar pathogens. Elias, Meysman, Bartholomeus et al. wanted to find out whether having preexisting memory CD4 T cells confers an advantage for vaccine-induced immunity. Thirty-four people who were never exposed to hepatitis B or ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/grantAgreement/EC/fwo/1861219N; info:eu-repo/semantics/altIdentifier/isi/000758103900001 |
| الاتاحة: | https://hdl.handle.net/10067/1852060151162165141 https://repository.uantwerpen.be/docstore/d:irua:10778 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7E3AF815 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |