Academic Journal
Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals
| العنوان: | Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals |
|---|---|
| المؤلفون: | Sha, Zhiqiang, Pepe, Antonietta, Schijven, Dick, Carrion-Castillo, Amaia, Roe, James Michael, Westerhausen, Rene, Joliot, Marc, Fisher, Simon E, Crivello, Fabrice, Francks, Clyde |
| المصدر: | 0027-8424. |
| بيانات النشر: | The National Academy of Sciences |
| سنة النشر: | 2022 |
| المجموعة: | Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
| الوصف: | Roughly 10% of the human population is left-handed, and this rate is increased in some brain-related disorders. The neuroanatomical correlates of hand preference have remained equivocal. We resampled structural brain image data from 28,802 right-handers and 3,062 left-handers (UK Biobank population dataset) to a symmetrical surface template, and mapped asymmetries for each of 8,681 vertices across the cerebral cortex in each individual. Left-handers compared to right-handers showed average differences of surface area asymmetry within the fusiform cortex, the anterior insula, the anterior middle cingulate cortex, and the precentral cortex. Meta-analyzed functional imaging data implicated these regions in executive functions and language. Polygenic disposition to left-handedness was associated with two of these regional asymmetries, and 18 loci previously linked with left-handedness by genome-wide screening showed associations with one or more of these asymmetries. Implicated genes included six encoding microtubule-related proteins: TUBB , TUBA1B , TUBB3 , TUBB4A , MAP2 , and NME7 —mutations in the latter can cause left to right reversal of the visceral organs. There were also two cortical regions where average thickness asymmetry was altered in left-handedness: on the postcentral gyrus and the inferior occipital cortex, functionally annotated with hand sensorimotor and visual roles. These cortical thickness asymmetries were not heritable. Heritable surface area asymmetries of language-related regions may link the etiologies of hand preference and language, whereas nonheritable asymmetries of sensorimotor cortex may manifest as consequences of hand preference. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | http://urn.nb.no/URN:NBN:no-93554; Sha, Zhiqiang Pepe, Antonietta Schijven, Dick Carrion-Castillo, Amaia Roe, James Michael Westerhausen, Rene Joliot, Marc Fisher, Simon E Crivello, Fabrice Francks, Clyde . Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals. Proceedings of the National Academy of Sciences of the United States of America. 2021, 118(47), 1-9; http://hdl.handle.net/10852/90972; 1990192; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Proceedings of the National Academy of Sciences of the United States of America&rft.volume=118&rft.spage=1&rft.date=2021; Proceedings of the National Academy of Sciences of the United States of America; 118; 47; https://doi.org/10.1073/pnas.2113095118; URN:NBN:no-93554; Fulltext https://www.duo.uio.no/bitstream/handle/10852/90972/1/e2113095118.full.pdf |
| DOI: | 10.1073/pnas.2113095118 |
| الاتاحة: | http://hdl.handle.net/10852/90972 http://urn.nb.no/URN:NBN:no-93554 https://doi.org/10.1073/pnas.2113095118 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.7E3A7C33 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1073/pnas.2113095118 |
|---|