Academic Journal
Evolutionary plasticity in the innate immune function of Akirin
| العنوان: | Evolutionary plasticity in the innate immune function of Akirin |
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| المؤلفون: | Polanowska, Jolanta, Chen, Jia-Xuan, Soule, Julien, Omi, Shizue, Belougne, Jérôme, Taffoni, Clara, Pujol, Nathalie, Selbach, Matthias, Zugasti, Olivier, Ewbank, Jonathan, J. |
| المساهمون: | Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Max Delbrück Center for Molecular Medicine Berlin (MDC), Helmholtz-Gemeinschaft = Helmholtz Association, ANR-12-BSV3-0001,FUN-EL,Immunité innée anti-fongique chez C. elegans(2012), ANR-16-CE15-0001,ELEGINN,Analyse intégrée de l'immunité innée antifongique chez C. elegans(2016), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011) |
| المصدر: | ISSN: 1553-7390. |
| بيانات النشر: | HAL CCSD Public Library of Science |
| سنة النشر: | 2018 |
| المجموعة: | Aix-Marseille Université: HAL |
| مصطلحات موضوعية: | Caenorhabditis elegans, Epidermis, Gene regulation, Immunoprecipitation, Chromatin, Transcription factors, Gene expression, RNA interference, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.IMM]Life Sciences [q-bio]/Immunology |
| الوصف: | International audience ; Eukaryotic gene expression requires the coordinated action of transcription factors, chromatin remodelling complexes and RNA polymerase. The conserved nuclear protein Akirin plays a central role in immune gene expression in insects and mammals, linking the SWI/SNF chromatin-remodelling complex with the transcription factor NFκB. Although nematodes lack NFκB, Akirin is also indispensable for the expression of defence genes in the epidermis of Caenorhabditis elegans following natural fungal infection. Through a combination of reverse genetics and biochemistry, we discovered that in C. elegans Akirin has conserved its role of bridging chromatin-remodellers and transcription factors, but that the identity of its functional partners is different since it forms a physical complex with NuRD proteins and the POU-class transcription factor CEH-18. In addition to providing a substantial step forward in our understanding of innate immune gene regulation in C. elegans, our results give insight into the molecular evolution of lineage-specific signalling pathways. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/30036395; hal-02108805; https://hal.science/hal-02108805; https://hal.science/hal-02108805/document; https://hal.science/hal-02108805/file/journal.pgen.1007494.pdf; PUBMED: 30036395 |
| DOI: | 10.1371/journal.pgen.1007494 |
| الاتاحة: | https://hal.science/hal-02108805 https://hal.science/hal-02108805/document https://hal.science/hal-02108805/file/journal.pgen.1007494.pdf https://doi.org/10.1371/journal.pgen.1007494 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.7E1A5E62 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pgen.1007494 |
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