التفاصيل البيبلوغرافية
| العنوان: |
DataSheet_1_Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case.docx |
| المؤلفون: |
Kevin M. Vannella (11816045), Cihan Oguz (561897), Sydney R. Stein (11816048), Stefania Pittaluga (243753), Esra Dikoglu (11126616), Arjun Kanwal (11816051), Sabrina C. Ramelli (11816054), Thomas Briese (67195), Ling Su (342547), Xiaolin Wu (1682056), Marcos J. Ramos-Benitez (10573391), Luis J. Perez-Valencia (11816057), Ashley Babyak (11816060), Nu Ri Cha (11816063), Joon-Yong Chung (573772), Kris Ylaya (265400), Ronson J. Madathil (9661043), Kapil K. Saharia (3160167), Thomas M. Scalea (11816066), Quincy K. Tran (11816069), Daniel L. Herr (7506527), David E. Kleiner (9332524), Stephen M. Hewitt (190750), Luigi D. Notarangelo (6467552), Alison Grazioli (7399430), Daniel S. Chertow (10573400) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, MIS-A, myocarditis, SARS-CoV-2, T cell receptor (TCR), SARS-CoV-2 epitopes, CDR3 sequences, cd-hit |
| الوصف: |
A 26-year-old otherwise healthy man died of fulminant myocarditis. Nasopharyngeal specimens collected premortem tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathological evaluation of the heart showed myocardial necrosis surrounded by cytotoxic T-cells and tissue-repair macrophages. Myocardial T-cell receptor (TCR) sequencing revealed hyper-dominant clones with highly similar sequences to TCRs that are specific for SARS-CoV-2 epitopes. SARS-CoV-2 RNA was detected in the gut, supporting a diagnosis of multisystem inflammatory syndrome in adults (MIS-A). Molecular targets of MIS-associated inflammation are not known. Our data indicate that SARS-CoV-2 antigens selected high-frequency T-cell clones that mediated fatal myocarditis. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/DataSheet_1_Evidence_of_SARS-CoV-2-Specific_T-Cell-Mediated_Myocarditis_in_a_MIS-A_Case_docx/17150045 |
| DOI: |
10.3389/fimmu.2021.779026.s001 |
| الاتاحة: |
https://doi.org/10.3389/fimmu.2021.779026.s001 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.7E0DD196 |
| قاعدة البيانات: |
BASE |