Academic Journal
Supplementary Figures S1-9 from MIG6 Mediates Adaptive and Acquired Resistance to ALK/ROS1 Fusion Kinase Inhibition through EGFR Bypass Signaling
| العنوان: | Supplementary Figures S1-9 from MIG6 Mediates Adaptive and Acquired Resistance to ALK/ROS1 Fusion Kinase Inhibition through EGFR Bypass Signaling |
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| المؤلفون: | Nan Chen, Logan C. Tyler, Anh T. Le, Eric A. Welsh, Bin Fang, Andrew Elliott, Kurtis D. Davies, Thomas Danhorn, Gregory J. Riely, Marc Ladanyi, Eric B. Haura, Robert C. Doebele |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Cancer, Cancer Detection and Diagnosis, Therapeutic Research and Development, Clinical Research and Trials, Biomarkers, Drug Resistance, Lung Cancer, Precision Medicine, Translational Research |
| الوصف: | Supplementary Figure S1. MIG6 protein reduction correlates with the responsiveness to ALK/ROS1 inhibitors. Supplementary Figure S2. MIG6 expression is decreased by ALK/ROS1 inhibition via the MAPK pathway. Supplementary Figure S3. Gefitinib restores sensitivity to ALK/ROS1 inhibition with MIG6 knockdown. Supplementary Figure S4. MIG6 siRNA knockdown rescues of SHC1-MAPK signaling under crizotinib treatments. Supplementary Figure S5. MIG6 mediates adaptive resistance to KRASG12C inhibition. Supplementary Figure S6. EGFR or ERBB2 amplification was not found in CUTO37-ER cells. Supplementary Figure S7. MIG6 protein is reduced in HCC78-TR and PR2 cells compared to their parental counterparts. Supplementary Figure S8. ERRFI1 alterations in pan-cancer. Supplementary Figure S9. Model depicting MIG6 role in regulating EGFR-mediated adaptive and acquired resistance to ALK/ROS1 inhibition. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Supplementary_Figures_S1-9_from_MIG6_Mediates_Adaptive_and_Acquired_Resistance_to_ALK_ROS1_Fusion_Kinase_Inhibition_through_EGFR_Bypass_Signaling/24935430 |
| DOI: | 10.1158/1535-7163.24935430.v1 |
| الاتاحة: | https://doi.org/10.1158/1535-7163.24935430.v1 https://figshare.com/articles/journal_contribution/Supplementary_Figures_S1-9_from_MIG6_Mediates_Adaptive_and_Acquired_Resistance_to_ALK_ROS1_Fusion_Kinase_Inhibition_through_EGFR_Bypass_Signaling/24935430 |
| Rights: | CC BY |
| رقم الانضمام: | edsbas.7DFA5C1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1158/1535-7163.24935430.v1 |
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