Academic Journal
Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice
| العنوان: | Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice |
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| المؤلفون: | Ezeja, Maxwell I., Onoja, Samuel O., Omeh, Yusuf N., Chibiko, Chijioke A. |
| المصدر: | International Journal of Basic & Clinical Pharmacology; Vol. 4 No. 3 (2015): May-June 2015; 453-457 ; 2279-0780 ; 2319-2003 |
| بيانات النشر: | Medip Academy |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Operculina turpethum, Analgesic, Antioxidant, Acetic acids, Pentazocine, Tail flick response |
| الوصف: | Background: Operculina turpethum Linn. (Convolvulaceae) is commonly called “Trivrit” or “India jalap” in English. It is a perennial herbaceous plant with purplish stem and milky-white exudates. This study was aimed at evaluation of the analgesic and antioxidant effects of the methanolic extract of O. turpethum leaves in mice.Methods: The acute oral toxicity of the extract was evaluated using up and down method. The analgesic effects were assessed using acetic acid-induced abdominal writhing reflex and tail flick methods, while the antioxidant activity (AA) was assayed using photometric 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging assay method.Results: The extract produced a concentration-dependent increase in the AA with inhibitory concentration 50% >400 µg/ml. The extract (100, 200 and 400 mg/kg) and aspirin (100 mg/kg) produced a significant (p<0.05) dose-dependent reduction in the number of abdominal constriction induced by intraperitoneal injection of acetic acid in treated mice when compared to the distilled water treated mice. The extract (100, 200, and 400 mg/kg) and pentazocine (3 mg/kg) caused a significant (p<0.05) dose-dependent increase in the pain reaction time in the treated mice groups, when compared to the distilled water treated groups.Conclusion: The study showed that O. turpethum possesses analgesic and antioxidant properties and confirmed the folkloric use of O. turpethum leaves in the traditional pain management. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://www.ijbcp.com/index.php/ijbcp/article/view/765/696; https://www.ijbcp.com/index.php/ijbcp/article/view/765 |
| DOI: | 10.18203/2319-2003.ijbcp20150015 |
| الاتاحة: | https://www.ijbcp.com/index.php/ijbcp/article/view/765 https://doi.org/10.18203/2319-2003.ijbcp20150015 |
| Rights: | Copyright (c) 2017 International Journal of Basic & Clinical Pharmacology |
| رقم الانضمام: | edsbas.7DDA0FBA |
| قاعدة البيانات: | BASE |
| DOI: | 10.18203/2319-2003.ijbcp20150015 |
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