التفاصيل البيبلوغرافية
| العنوان: |
Photodynamic Therapy With Bengal Rose and Derivatives Against Leishmania amazonensis |
| المؤلفون: |
Navasconi, Taisa Rocha, dos Reis, Vanessa Nesi, Freitas, Camila Fabiano, Pereira, Paulo Cesar Souza, Caetano, Wilker, Hioka, Noboru, Lonardoni, Maria Valdrinez Campana, Aristides, Sandra Mara Alessi, Silveira, Thaís Gomes Verzignassi |
| المصدر: |
Journal of Lasers in Medical Sciences; Vol. 8 No. 1 (2017): Winter; 46-50 ; 2228-6721 ; 2008-9783 |
| بيانات النشر: |
Shahid Beheshti University of Medical Sciences |
| سنة النشر: |
2017 |
| المجموعة: |
Portal of Scientific Journals at Shahid Beheshti University of Medical Science |
| مصطلحات موضوعية: |
Cutaneous leishmaniasis, Photodynamic therapy, Leishmania amazonensis, Xanthenes, Rose Bengal B |
| الوصف: |
Introduction: The treatment of cutaneous leishmaniasis (CL) is based primarily on the use of pentavalent antimonials, which may lead to many side effects limiting their use. Photodynamic therapy (PDT) is an alternative for the treatment of CL, and some xanthene dyes have the potential for use in PDT.Methods: The xanthenes rose bengal B (RB) and its derivatives rose bengal methyl ester (RBMET), and butyl ester (RBBUT) were analyzed for leishmanicidal activity against promastigotes and intracellular amastigotes of Leishmania amazonensis. Cytotoxicity was assessed in J774.A1 macrophages.Results: RB derivates RBMET (IC50 9.83 μM), and RBBUT (IC50 45.08 μM) showed leishmanicidal activity, however, were toxic to J774.A1 macrophages, resulting in low selectivity index.Conclusion: The RBMET and RBBUT showed to be effective against the L. amazonensis and the low selectivity index presented may not be a limitation for their use in PDT to CL treatment. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://journals.sbmu.ac.ir/jlms/article/view/13385/13385; https://journals.sbmu.ac.ir/jlms/article/view/13385 |
| الاتاحة: |
https://journals.sbmu.ac.ir/jlms/article/view/13385 |
| Rights: |
Copyright (c) 2017 Journal of Lasers in Medical Sciences |
| رقم الانضمام: |
edsbas.7DC629E9 |
| قاعدة البيانات: |
BASE |