التفاصيل البيبلوغرافية
| العنوان: |
Differential EDS1 requirement for cell death activities of plant TIR-domain proteins |
| المؤلفون: |
Johanndrees, Oliver, Baggs, Erin, Uhlmann, Charles, Locci, Federica, Laessle, Henriette L., Melkonian, Katharina, Kaeufer, Kiara, Dongus, Joram A, Nakagami, Hirofumi, Krasileva, Ksenia V, Parker, Jane E., Lapin, Dmitry |
| المساهمون: |
Sub Plant-Microbe Interactions, Plant Microbe Interactions |
| بيانات النشر: |
bioRxiv |
| سنة النشر: |
2021 |
| الوصف: |
Toll/interleukin-1 Receptor (TIR) domains are integral to immune systems across all domains of life. TIRs exist as single-domain and as larger receptor or adaptor proteins. In plants, TIRs constitute N-terminal domains of nucleotide-binding leucine-rich repeat (NLR) immune receptors. Although TIR-NLR and TIR signaling requires the Enhanced disease susceptibility 1 (EDS1) protein family, TIR domains persist in species that have incomplete or no EDS1 members. To assess whether particular TIR groups appear with EDS1, we searched for TIR-EDS1 co-occurrence patterns. Using a large-scale phylogenetic analysis of TIR domains from 39 algae and land plant species, we identify four conserved TIR groups, two of which are TIR-NLRs present in eudicots and two are more widespread. Presence of one TIR-only protein group is highly correlated with EDS1 and members of this group elicit EDS1-dependent cell death. By contrast, a more widely represented TIR group of TIR-NB-WD40/TPR (TNP) proteins (formerly called XTNX) has at least one member which can induce EDS1-independent cell death. Our data provide a new phylogeny-based plant TIR classification and identify TIR groups that appear to have evolved with and are dependent on EDS1, while others have EDS1-independent activity. |
| نوع الوثيقة: |
report |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://dspace.library.uu.nl/handle/1874/415197 |
| الاتاحة: |
https://dspace.library.uu.nl/handle/1874/415197 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.7D93F13D |
| قاعدة البيانات: |
BASE |