Academic Journal
Running title: TCDD Effects in Developing Mouse Paw
| العنوان: | Running title: TCDD Effects in Developing Mouse Paw |
|---|---|
| المؤلفون: | Jeffrey C. Bemis, Napoleon F. Alej, Daniel A. Nazarenko, Andrew I, Raymond B. Baggs, Thomas A. Gasiewicz |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://toxsci.oxfordjournals.org/cgi/reprint/kfl132v1.pdf. |
| سنة النشر: | 2006 |
| المجموعة: | CiteSeerX |
| الوصف: | 1 The Aryl-hydrocarbon Receptor (AhR) is a ligand-dependent transcription factor that mediates the toxicity of certain halogenated aromatic hydrocarbons including 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD). These compounds are potent developmental toxicants that can alter gene expression and disrupt processes of proliferation and differentiation. It has not yet been determined which tissues during development are most sensitive to these compounds, nor which genes are directly associated with the toxicities. We developed a transgenic mouse model to delineate the temporal and spatial context of transcriptionally active AhR by utilizing a Dioxin Responsive Element (DRE)-linked LacZ reporter system. The present study focuses on the pattern of TCDD-induced transgene expression localized to the footpad and digits of the paws between gestational days (GD) 13 and 18. Paw morphology was evaluated at several developmental stages following TCDD exposure. Gene |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.119.8565; http://toxsci.oxfordjournals.org/cgi/reprint/kfl132v1.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.119.8565 http://toxsci.oxfordjournals.org/cgi/reprint/kfl132v1.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.7D90B09 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |