التفاصيل البيبلوغرافية
| العنوان: |
Recurrent laryngeal nerve injury after esophagectomy for esophageal cancer: Incidence, management, and impact on shortand long-term outcomes |
| المؤلفون: |
Scholtemeijer, Martijn G., Seesing, Maarten F.J., Brenkman, Hylke J.F., Janssen, Luuk M., van Hillegersberg, Richard, Ruurda, Jelle P. |
| المساهمون: |
MS CGO, Cancer, MS KNO, Other research (not in main researchprogram), Divisie Beeld & Oncologie |
| سنة النشر: |
2017 |
| مصطلحات موضوعية: |
Esophagectomy, Pneumonia, Recurrent laryngeal nerve (RLN), RLN injuries, Vocal cord paralysis, Pulmonary and Respiratory Medicine, Journal Article |
| الوصف: |
Background: Recurrent laryngeal nerve (RLN) injury caused by esophagectomy may lead to postoperative morbidity, however data on long-term recovery are scarce. The aim of this study was to evaluate the consequences of RLN palsy (RLNP) in terms of pulmonary morbidity and long-term functional recovery. Methods: Patients who underwent a 3-stage transthoracic (McKeown) or a transhiatal esophagectomy for esophageal carcinoma in the University Medical Center Utrecht (UMCU) between January 2004 and March 2016 were included from a prospective database. Multivariable analyses were conducted to assess the association between RLNP and pulmonary complications and hospital stay. Data regarding long-term recovery were summarized using descriptive statistics. Results: Out of the 451 included patients, 47 (10%) were diagnosed with RLNP. Of the patients with RLNP, 34 (7%) had a unilateral lesion, 8 (2%) had a bilateral lesion, and in 5 (1%) the location of the lesion was unknown. The incidence of RLNP was 3/127 (2%) in the transhiatal group, and 44/324 (14%) in the McKeown group. RLNP after McKeown esophagectomy was associated with a higher incidence of pulmonary complications (OR 2.391; 95% CI 1.222-4.679; P=0.011), as well as a longer hospital stay (+4 days) (P=0.001). Of the RLNP patients with more than 6 months follow up almost half recovered fully (median follow-up of 17.5 [7-135] months). Of the remainder, six required a surgical intervention and the others had residual symptoms. Conclusions: RLNP after McKeown esophagectomy is associated with an increased pulmonary complication rate, longer hospital stay, and a moderate long-term recovery. Further studies are necessary that examine technologies, which may reduce RLNP incidence and contribute to the early detection and treatment of RLNP. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
image/pdf |
| اللغة: |
English |
| تدمد: |
2072-1439 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/355899 |
| الاتاحة: |
https://dspace.library.uu.nl/handle/1874/355899 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.7D7F71CD |
| قاعدة البيانات: |
BASE |
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