Academic Journal
Small amounts of dietary medium-chain fatty acids protect against insulin resistance during caloric excess in humans.
| العنوان: | Small amounts of dietary medium-chain fatty acids protect against insulin resistance during caloric excess in humans. |
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| المؤلفون: | Lundsgaard, A.M., Fritzen, A.M., Sjøberg, K.A., Kleinert, M., Richter, E.A., Kiens, B. |
| المصدر: | Diabetes 70, 91-98 (2021) |
| بيانات النشر: | Amer Diabetes Assoc |
| سنة النشر: | 2021 |
| المجموعة: | PuSH - Publikationsserver des Helmholtz Zentrums München |
| الوصف: | Medium-chain fatty acids (MCFAs) have in rodents been shown to have protective effects on glucose homeostasis during high-fat overfeeding. In this study, we investigated whether dietary MCFAs protect against insulin resistance induced by a hypercaloric high-fat diet in humans. Healthy, lean men ingested a eucaloric control diet and a three-day hypercaloric high-fat diet (+75% energy, 81-83E% fat) in randomized order. For one group (n=8), the high-fat diet was enriched with saturated long-chain FAs (LCSFA-HFD), while the other group (n=9) ingested a matched diet, but with ∼30 g (5E%) saturated MCFAs (MCSFA-HFD) in substitution for a corresponding fraction of the saturated LCFAs. A hyperinsulinemic-euglycemic clamp with femoral arteriovenous balance and glucose tracer was applied after the control and hypercaloric diets. In LCSFA-HFD, whole body insulin sensitivity and peripheral insulin-stimulated glucose disposal were reduced. These impairments were prevented in MCSFA-HFD, accompanied by increased basal FA oxidation, maintained glucose metabolic flexibility, increased non-oxidative glucose disposal related to lower starting glycogen content and increased glycogen synthase activity, together with increased muscle lactate production. In conclusion, substitution of a small amount of dietary LCFAs with MCFAs rescues insulin action in conditions of lipid-induced energy excess. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0012-1797 1939-327X |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33122393; info:eu-repo/semantics/altIdentifier/wos/WOS:000600761400009; info:eu-repo/semantics/altIdentifier/isbn/0012-1797; info:eu-repo/semantics/altIdent; https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60655; urn:isbn:0012-1797; urn:issn:0012-1797; urn:issn:1939-327X |
| DOI: | 10.2337/db20-0582 |
| الاتاحة: | https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60655 https://doi.org/10.2337/db20-0582 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7D7DBFEB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00121797 1939327X |
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| DOI: | 10.2337/db20-0582 |