Academic Journal
Development of a Sensing Array for Human Breath Analysis Based on SWCNT Layers Functionalized with Semiconductor Organic Molecules
| العنوان: | Development of a Sensing Array for Human Breath Analysis Based on SWCNT Layers Functionalized with Semiconductor Organic Molecules |
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| المؤلفون: | Freddi, Sonia, Emelianov, Aleksei V., Bobrinetskiy, Ivan I., Drera, Giovanni, Pagliara, Stefania, Kopylova, Daria S., Chiesa, Maria, Santini, Giuseppe, Mores, Nadia, Moscato, Umberto, Nasibulin, Albert G., Montuschi, Paolo, Sangaletti, Luigi |
| المساهمون: | Department of Chemistry and Materials Science, Electrochemical Energy Conversion, Catholic University of the Sacred Heart, National Research University of Electronic Technology, Skolkovo Institute of Science and Technology, Policlinico Universitario Agostino Gemelli, Aalto-yliopisto, Aalto University |
| بيانات النشر: | John Wiley and Sons Ltd |
| سنة النشر: | 2020 |
| المجموعة: | Aalto University Publication Archive (Aaltodoc) / Aalto-yliopiston julkaisuarkistoa |
| مصطلحات موضوعية: | breathomics, carbon nanotubes, chronic obstructive pulmonary disease, electronic noses, hybrid heterojunctions, WALLED CARBON NANOTUBES, ELECTRONIC NOSE, LUNG-CANCER, GAS SENSORS, RESISTIVE SENSORS, VOC, BIOMARKERS, DISCRIMINATION, AMMONIA, OXIDE |
| الوصف: | A sensor array based on heterojunctions between semiconducting organic layers and single walled carbon nanotube (SWCNT) films is produced to explore applications in breathomics, the molecular analysis of exhaled breath. The array is exposed to gas/volatiles relevant to specific diseases (ammonia, ethanol, acetone, 2-propanol, sodium hypochlorite, benzene, hydrogen sulfide, and nitrogen dioxide). Then, to evaluate its capability to operate with real relevant biological samples the array is exposed to human breath exhaled from healthy subjects. Finally, to provide a proof of concept of its diagnostic potential, the array is exposed to exhaled breath samples collected from subjects with chronic obstructive pulmonary disease (COPD), an airway chronic inflammatory disease not yet investigated with CNT-based sensor arrays, and breathprints are compared with those obtained from of healthy subjects. Principal component analysis shows that the sensor array is able to detect various target gas/volatiles with a clear fingerprint on a 2D subspace, is suitable for breath profiling in exhaled human breath, and is able to distinguish subjects with COPD from healthy subjects based on their breathprints. This classification ability is further improved by selecting the most responsive sensors to nitrogen dioxide, a potential biomarker of COPD. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-85-08-51161-7 85-08-51161-2 |
| تدمد: | 2192-2640 20200625 |
| Relation: | ADVANCED HEALTHCARE MATERIALS; articlenumber 2000377; Freddi, S, Emelianov, A V, Bobrinetskiy, I I, Drera, G, Pagliara, S, Kopylova, D S, Chiesa, M, Santini, G, Mores, N, Moscato, U, Nasibulin, A G, Montuschi, P & Sangaletti, L 2020, ' Development of a Sensing Array for Human Breath Analysis Based on SWCNT Layers Functionalized with Semiconductor Organic Molecules ', Advanced Healthcare Materials, vol. 9, no. 12, 2000377 . https://doi.org/10.1002/adhm.202000377; PURE UUID: 1311ffb2-35a7-44a6-9564-dc47b1b0f2b8; PURE ITEMURL: https://research.aalto.fi/en/publications/1311ffb2-35a7-44a6-9564-dc47b1b0f2b8; PURE LINK: http://www.scopus.com/inward/record.url?scp=85085116129&partnerID=8YFLogxK; PURE FILEURL: https://research.aalto.fi/files/43452996/CHEM_Freddi_et_al_Development_of_a_sensing_array_Advanced_Healthcare_Materials.pdf; https://aaltodoc.aalto.fi/handle/123456789/45074; URN:NBN:fi:aalto-202006254031 |
| DOI: | 10.1002/adhm.202000377 |
| الاتاحة: | https://aaltodoc.aalto.fi/handle/123456789/45074 https://doi.org/10.1002/adhm.202000377 |
| Rights: | openAccess |
| رقم الانضمام: | edsbas.7D727B01 |
| قاعدة البيانات: | BASE |
| ردمك: | 9788508511617 8508511612 |
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| تدمد: | 21922640 20200625 |
| DOI: | 10.1002/adhm.202000377 |