Academic Journal
Herpes simplex virus evasion of early host antiviral responses
| العنوان: | Herpes simplex virus evasion of early host antiviral responses |
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| المؤلفون: | Tognarelli Torres, Eduardo Ignacio, Palomino Poblete, Tomás Francisco, Corrales Bonilla, Nicolás, Bueno Ramírez, Susan, Kalergis Parra. Alexis Mikes, González Muñoz, Pablo Alberto |
| سنة النشر: | 2024 |
| المجموعة: | Pontificia Universidad Católica de Chile: Repositorio UC |
| مصطلحات موضوعية: | Interferon (IFN), Inflammasome, Toll-like receptors (TLRs), Natural killer cells (NK cells), Dendritic cells (DCs), Cytosolic nucleic acid receptors, Innate immunity, Apoptosis, Medicina y salud, 03 Good Health and Well-being, 03 Salud y bienestar |
| Time: | 610 |
| الوصف: | Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) have co-evolved with humans for thousands of years and are present at a high prevalence in the population worldwide. HSV infections are responsible for several illnesses including skin and mucosal lesions, blindness and even life-threatening encephalitis in both, immunocompetent and immunocompromised individuals of all ages. Therefore, diseases caused by HSVs represent significant public health burdens. Similar to other herpesviruses, HSV-1 and HSV-2 produce lifelong infections in the host by establishing latency in neurons and sporadically reactivating from these cells, eliciting recurrences that are accompanied by viral shedding in both, symptomatic and asymptomatic individuals. The ability of HSVs to persist and recur in otherwise healthy individuals is likely given by the numerous virulence factors that these viruses have evolved to evade host antiviral responses. Here, we review and discuss molecular mechanisms used by HSVs to evade early innate antiviral responses, which are the first lines of defense against these viruses. A comprehensive understanding of how HSVs evade host early antiviral responses could contribute to the development of novel therapies and vaccines to counteract these viruses. ; VRAID (ex DIPUC) |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-0-00-466523-8 0-00-466523-6 |
| تدمد: | 2235-2988 |
| Relation: | Tognarelli Torres Eduardo Igna, Bueno Ramirez Susan Marcela, Kalergis Parra Alexis Mikes, Gonzalez Munoz Pablo Alberto. Herpes Simplex Virus Evasion of Early Host Antiviral Responses. 2019;9:1-24.; https://doi.org/10.3389/fcimb.2019.00127; https://repositorio.uc.cl/handle/11534/80946; WOS:000466523600001 |
| DOI: | 10.3389/fcimb.2019.00127 |
| الاتاحة: | https://repositorio.uc.cl/handle/11534/80946 https://doi.org/10.3389/fcimb.2019.00127 |
| Rights: | acceso abierto ; Creative Commons Attribution License (CC BY) ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.7D441349 |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9780004665238 0004665236 |
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| تدمد: | 22352988 |
| DOI: | 10.3389/fcimb.2019.00127 |