Academic Journal
Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
| العنوان: | Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells |
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| المؤلفون: | Lee, Mi-Ok, Lee, Su-gi, Jung, Cho-Rok, Son, Ye Seul, Ryu, Jae-Woon, Jung, Kwang Bo, Ahn, Jun-Ho, Oh, Jung-Hwa, Lee, Hyang-Ae, Lim, Jung Hwa, Kim, Janghwan, Jang, Insu, Choi, Jinhyuk, Jung, Jaeeun, Park, Kunhyang, Lee, Byungwook, Kim, Dae-Soo, Son, Mi-Young, Cho, Hyun-Soo |
| المصدر: | Nature Communications ; volume 12, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| الوصف: | Human pluripotent stem cell (hPSC)-derived organoids and cells have similar characteristics to human organs and tissues. Thus, in vitro human organoids and cells serve as a superior alternative to conventional cell lines and animal models in drug development and regenerative medicine. For a simple and reproducible analysis of the quality of organoids and cells to compensate for the shortcomings of existing experimental validation studies, a quantitative evaluation method should be developed. Here, using the GTEx database, we construct a quantitative calculation system to assess similarity to the human organs. To evaluate our system, we generate hPSC-derived organoids and cells, and detected organ similarity. To facilitate the access of our system by researchers, we develop a web-based user interface presenting similarity to the appropriate organs as percentages. Thus, this program could provide valuable information for the generation of high-quality organoids and cells and a strategy to guide proper lineage-oriented differentiation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-021-24746-w |
| الاتاحة: | http://dx.doi.org/10.1038/s41467-021-24746-w https://www.nature.com/articles/s41467-021-24746-w.pdf https://www.nature.com/articles/s41467-021-24746-w |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.7D03FAAE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-021-24746-w |
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